Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy-Reference-Cited by-同舟云学术

Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy

Published:2023-06-30 Issue: Volume: Page:151-163
ISSN:
Container-title:Exploration of Neuroprotective Therapy
language:en
Short-container-title:Explor Neuroprot Ther

Author:

Avila Jesús¹^ORCID,Pérez Mar²^ORCID,Avila-Villanueva Marina³^ORCID,Santa-María Ismael⁴^ORCID,Hernández Félix⁵^ORCID

Affiliation:

1. Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas–Universidad Autónoma de Madrid (CSIC-UAM), 28049 Madrid, Spain; Networking Research Centre on Neurodegenerative Diseases, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain

2. Departamento de Anatomía Histología y Neurociencia, Facultad de Medicina, Universidad Autónoma de Madrid (UAM), 28029 Madrid, Spain

3. Departamento de Psicología Experimental, Procesos Cognitivos y Logopedia, Universidad Complutense de Madrid, 28040 Madrid, Spain

4. Facultad de Ciencias Experimentales, Universidad Francisco de Vitoria, 28223 Madrid, Spain

5. Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas–Universidad Autónoma de Madrid (CSIC-UAM), 28049 Madrid, Spain

Abstract

Currently, the predominant targets for the treatment of Alzheimer’s disease (AD) are the main components of the two pathological structures: senile plaques (composed of amyloid beta peptide aggregates) or neurofibrillary tangles (constructed of tau protein polymers). However, the existence of adequate disease modifiers based on such targets is discussed. In this special issue, it has been suggested to search for new possible targets for AD therapy. This contribution tries to analyze non-neuronal tissues (periphery) to identify potential factors (target) involved in the development of AD.

Funder

Ministerio de Ciencia e Innovación

Publisher

Open Exploration Publishing

Subject

General Earth and Planetary Sciences,General Engineering,General Environmental Science,General Medicine,General Earth and Planetary Sciences,General Environmental Science,Materials Chemistry,Economics and Econometrics,Media Technology,Forestry,Pharmacology (medical),Complementary and alternative medicine,Pharmaceutical Science,General Medicine,Immunology and Allergy,Applied Mathematics,General Mathematics,Pulmonary and Respiratory Medicine,Pediatrics, Perinatology, and Child Health,Microbiology

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