The potential positive effects of coenzyme Q10 on the regeneration of peripheral nerve injury

Author:

Mead Ahmed1ORCID,Delibaş Burcu2ORCID,Önger Mehmet Emin3ORCID,Kaplan Süleyman4ORCID

Affiliation:

1. Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Simad University, Mogadishu 999128, Somalia

2. Department of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdoğan University, 53020 Rize, Türkiye

3. Department of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, 55139 Samsun, Türkiye

4. Department of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, 55139 Samsun, Türkiye; Department of Health and Biomedical Sciences, School of Life Science and Bioengineering, Nelson Mandela African Institution of Science and Technology, Arusha 23311, Tanzania

Abstract

Peripheral nerve injuries (PNIs) constitute a significant concern as they predominantly affect young and productive age groups of the population, causing social and economic pressure on patients. PNIs are a global problem that can result in disability because of the disruption of nerve function. PNI leads to a reduction in nerve conduction velocity, which worsens or impairs the mobility of the innervated area. Managing PNI remains a major clinical challenge. Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant first identified in 1957. It is an important antioxidant necessary for the organs to maintain their normal function and the body’s chemical processes. It scavenges free radicals and reduces oxidative stress. Studies showed that antioxidants such as CoQ10 a potent antioxidant, help the regeneration of PNIs. It has been observed to increase the myelination process in nerve fibres and promote nerve regeneration in rats after injury. Therefore, this review handles the current positive effects of CoQ10 on peripheral nerve regeneration following injury.

Publisher

Open Exploration Publishing

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