Cognitive-motor interference in multiple sclerosis and healthy controls: results from single, dual, and triple task posturography-Reference-Cited by-同舟云学术

Cognitive-motor interference in multiple sclerosis and healthy controls: results from single, dual, and triple task posturography

Published:2024-06-12 Issue: Volume: Page:273-287
ISSN:
Container-title:Exploration of Neuroprotective Therapy
language:en
Short-container-title:Explor Neuroprot Ther

Author:

Althoff Patrik¹^ORCID,Rosenthal Friederike²,Dorsch Eva-Maria³^ORCID,Drebinger Daniel⁴^ORCID,Arsenova Radina¹,Chorschew Anna¹^ORCID,Rosenkranz Sina C.²^ORCID,Bellmann-Strobl Judith³,Heesen Christoph²,Paul Friedemann⁵^ORCID,Weygandt Martin¹^ORCID,Schmitz-Hübsch Tanja³^ORCID

Affiliation:

1. Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany

2. Institut für Neuroimmunologie und Multiple Sklerose (INIMS), Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, 20251 Hamburg, Germany

3. Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany; Neuroscience Clinical Research Center, Charité – Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany

4. Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany; Department of Physical Medicine and Rehabilitation, Charité – Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany

5. Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany; Neuroscience Clinical Research Center, Charité – Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany; Department of Neurology and Experimental Neurology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany

Abstract

Aim: This article is based on our previous research, which was presented as a poster at the ECTRIMS Congress 2018 and published as a conference abstract (https://www.professionalabstracts.com/ectrims2018/iplanner/#/presentation/1698). Cognitive-motor interference (CMI) has been observed in both healthy controls (HC) and persons with multiple sclerosis (pwMS), but limited and contradictory data is making it difficult to assess the impact of motor and cognitive functioning levels on CMI. The aim of this study was to investigate CMI in pwMS and HC by means of a dual task postural paradigm, to compare them between groups and to analyse the influence of motor and cognitive functioning levels assessed with complementary instruments on observed CMI. Methods: The dual task posturography paradigm serves to quantify the impact of a cognitive (i.e., performing serial subtractions), a motor challenge (closing eyes), or both challenges combined (triple task) on body sway during standing in an upright position feet closed. The data analysed were acquired in one interventional and four observational studies and selected based on predefined criteria and by systematic quality control. A total of 113 pwMS and 42 HC were selected for analysis. Results: Comparable changes in motor and cognitive performance due to cognitive or combined cognitive-motor challenges were observed in both HC and pwMS. Combining both tasks did not result in further changes in motor performance but resulted in a decrease in cognitive performance. This reduction in cognitive performance with an additional motor challenge correlated with lower levels of cognitive and motor functioning in pwMS. Unexpectedly, an increase in body sway due to a cognitive or combined cognitive-motor challenges was primarily observed in pwMS and HC with better cognitive and motor functioning. Conclusions: The results suggest that dual-task effects are not disease-specific but rather reflect individually different adaptation strategies depending on the specific motor and cognitive functioning levels.

Publisher

Open Exploration Publishing

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