Should we rethink neurodegeneration?

Author:

Sipilä Jussi O.T.1ORCID

Affiliation:

1. Department of Neurology, Siun Sote North Karelia Central Hospital, FI-80210 Joensuu, Finland; Clinical Neurosciences, University of Turku, FI-20521 Turku, Finland

Abstract

The therapy of many neurological disorders has advanced markedly during recent decades. Not so for neurodegenerative disorders. Early detection, deep individual genotyping and phenotyping, and personalized therapies have been suggested as the way forward. However, we still do not know enough about the aetiology and molecular basics of these diseases. In fact, the term neurodegenerative disorder may be a misleading categorization that constitutes a major cognitive barrier against better characterization and understanding of these disorders. Therefore, we need to go back to the basics and employ novel, open-minded observational study protocols that combine very extensive and robust clinical, molecular and epidemiological data collection methods. Moreover, we need to reconsider our basic orientation towards these diseases to increase our chances of finding out what we are actually trying to care for and cure.

Publisher

Open Exploration Publishing

Subject

Marketing,Strategy and Management,Economics and Econometrics,Finance,Accounting,Business and International Management,Management of Technology and Innovation,Business and International Management,Management of Technology and Innovation,Business and International Management,Marketing,Management Information Systems,Physiology (medical),Orthopedics and Sports Medicine,Animal Science and Zoology,Energy Engineering and Power Technology,Fuel Technology,General Chemical Engineering,History,Cultural Studies,Oncology

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