The impact of tumour pH on cancer progression: strategies for clinical intervention-Reference-Cited by-同舟云学术

The impact of tumour pH on cancer progression: strategies for clinical intervention

Published:2020-04-09 Issue:2 Volume:1 Page:71-100
ISSN:
Container-title:Exploration of Targeted Anti-tumor Therapy
language:
Short-container-title:

Author:

Ward Carol¹,Meehan James¹,Gray Mark E²,Murray Alan F³,Argyle David J²,Kunkler Ian H¹,Langdon Simon P¹

Affiliation:

1. Cancer Research UK Edinburgh Centre and Edinburgh Pathology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, EH4 2XU Edinburgh, UK

2. Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush, EH25 9RG Midlothian, UK

3. School of Engineering, Institute for Integrated Micro and Nano Systems, EH9 3JL Edinburgh, UK

Abstract

Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX, the monocarboxylate transporters (MCT, MCT1 and MCT4), the vacuolar-type H+-ATPase proton pump, and the sodium-hydrogen exchanger 1. This review will describe progress in the development of inhibitors to these targets.

Funder

Edinburgh and Lothians Health Foundation

Seventh Framework Programme

Engineering and Physical Sciences Research Council

Publisher

Open Exploration Publishing

Reference283 articles.

1. Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A. 1995;92:5510-4.

2. Doe MR, Ascano JM, Kaur M, Cole MD. Myc posttranslationally induces HIF1 protein and target gene expression in normal and cancer cells. Cancer Res. 2011;72:949-57.

3. Ippolito L, Morandi A, Giannoni E, Chiarugi P. Lactate: a metabolic driver in the tumour landscape. Trends Biochem Sci. 2019;44:153-66.

4. Warburg O. On respiratory impairment in cancer cells. Science. 1956;124:269-70.

5. Ward C, Langdon SP, Mullen P, Harris AL, Harrison DJ, Supuran CT, et al. New strategies for targeting the hypoxic tumour microenvironment in breast cancer. Cancer Treat Rev. 2013;39:171-9.

Cited by 71 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Exercise therapy: Anti-tumor and improving chemotherapy efficacy;Journal of Holistic Integrative Pharmacy;2024-09

2. Plant flavonol quercetin engenders cytotoxic effect in different pre-clinical cancer models through modulation of diverse epigenetic regulators;The Nucleus;2024-08-13

3. Stimuli-Responsive Nanocomposite Hydrogels for Oral Diseases;Gels;2024-07-18

4. Roles of the oncometabolite enantiomers of 2-hydroxyglutarate and their metabolism by diverse dehydrogenases;Essays in Biochemistry;2024-06-26

5. Exploring the Potential Use of Natural Products Together with Alkalization in Cancer Therapy;Pharmaceutics;2024-06-10