Role of PI3K/Akt/mTOR pathway in mediating endocrine resistance: concept to clinic-Reference-Cited by-同舟云学术

Role of PI3K/Akt/mTOR pathway in mediating endocrine resistance: concept to clinic

Published:2022-04-24 Issue: Volume: Page:172-199
ISSN:2692-3114
Container-title:Exploration of Targeted Anti-tumor Therapy
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Author:

Skolariki Aglaia¹^ORCID,D’Costa Jamie¹^ORCID,Little Martin²^ORCID,Lord Simon¹^ORCID

Affiliation:

1. Department of Oncology, University of Oxford, Churchill Hospital, OX3 7LE Oxford, UK

2. Department of Oncology, Churchill Hospital, OX3 7LE Oxford, UK

Abstract

The majority of breast cancers express the estrogen receptor (ER) and for this group of patients, endocrine therapy is the cornerstone of systemic treatment. However, drug resistance is common and a focus for breast cancer preclinical and clinical research. Over the past 2 decades, the PI3K/Akt/mTOR axis has emerged as an important driver of treatment failure, and inhibitors of mTOR and PI3K are now licensed for the treatment of women with advanced ER-positive breast cancer who have relapsed on first-line hormonal therapy. This review presents the preclinical and clinical data that led to this new treatment paradigm and discusses future directions.

Publisher

Open Exploration Publishing

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference193 articles.

1. Turner NC, Neven P, Loibl S, Andre F. Advances in the treatment of advanced oestrogen-receptor-positive breast cancer. Lancet. 2017;389:2403–14.

2. Walsh EM, Smith KL, Stearns V. Management of hormone receptor-positive, HER2-negative early breast cancer. Semin Oncol. 2020;47:187–200.

3. Vanhaesebroeck B, Stephens L, Hawkins P. PI3K signalling: the path to discovery and understanding. Nat Rev Mol Cell Biol. 2012;13:195–203.

4. Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT. The PI3K pathway in human disease. Cell. 2017;170:605–35.

5. Whitman M, Downes CP, Keeler M, Keller T, Cantley L. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature. 1988;332:644–6.

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