Epigenetics in etiopathology of hyperprolactinemia-Reference-Cited by-同舟云学术

Epigenetics in etiopathology of hyperprolactinemia

Published:2024-05-22 Issue:2 Volume:1 Page:39-55
ISSN:
Container-title:Exploration of Endocrine and Metabolic Diseases
language:
Short-container-title:Explor Endocr Metab Dis

Author:

Kalsi Amanpreet Kaur¹^ORCID,Halder Ashutosh²^ORCID,Jain Manish²^ORCID,Sharma Jai Bhagwan³

Affiliation:

1. Department of Zoology, Dyal Singh College, Karnal, Haryana 132001, India

2. Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi 110029, India

3. Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi 110029, India

Abstract

Aim: Epigenetic alterations have been reported in patients with pituitary tumors and those on antipsychotic drugs, which are also responsible for hyperprolactinemia. This suggests a possible role of epigenetics in the etiopathology of hyperprolactinemia. Methods: The study recruited 83 hyperprolactinemia cases with prolactin > 100 ng/mL and 65 controls. Global DNA methylation status was studied by MethylFlash Methylated DNA Quantification Kit and genome-wide methylation analysis (GWMA) by Infinium Methylation EPIC BeadChip 850K array. Results: Hyperprolactinemia cases showed significant global DNA hypermethylation compared to controls. Around 66.67% of hypomethylated and 12.9% of hypermethylated cases were on antipsychotics. Gene enrichment analysis of 5-cytosine-phosphate-guanine-3 (CpG) site-associated genes demonstrated significantly enriched major histocompatibility complex (MHC)-related protein classes and cellular components. Conclusions: The study suggested the role of epigenetics in the etiopathology of hyperprolactinemia.

Publisher

Open Exploration Publishing

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