Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury-Reference-Cited by-同舟云学术

Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury

Published:2023-06-28 Issue: Volume: Page:83-99
ISSN:
Container-title:Exploration of Digestive Diseases
language:en
Short-container-title:Explor Dig Dis

Author:

Wu Hanghang¹^ORCID,Bao Xiyuan²^ORCID,Gutierrez Alejandro H.¹^ORCID,Nevzorova Yulia A.³^ORCID,Cubero Francisco Javier³^ORCID

Affiliation:

1. Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain

2. Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain; Department of General Surgery, No. 924 Hospital of Joint Logistics Support Force of PLA, Guilin 541002, Guangxi Zhuang Autonomous Region, China

3. Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28007 Madrid, Spain

Abstract

The pathogenesis of drug-induced liver injury (DILI) is still in an early stage of research. However, investigators have shown that both oxidative stress and endoplasmic reticulum (ER) stress play a significant role in the pathological mechanism. However, there is little in-depth literature about these two mechanisms. In order to prevent and improve the clinical symptoms of DILI, it is particularly important to study its pathogenesis. In this review article, the role of ER and oxidative stress in DILI is thoroughly discussed.

Funder

Ministerio de Ciencia e Innovación

Publisher

Open Exploration Publishing

Subject

Microbiology (medical),Immunology,Immunology and Allergy,General Earth and Planetary Sciences,Water Science and Technology,Geography, Planning and Development,General Agricultural and Biological Sciences,General Medicine,General Earth and Planetary Sciences,General Environmental Science,General Earth and Planetary Sciences,General Environmental Science,General Medicine

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