The impact of hepatitis B virus (HBV) splicing on HBV replication and disease progression-Reference-Cited by-同舟云学术

The impact of hepatitis B virus (HBV) splicing on HBV replication and disease progression

Published:2024-08-07 Issue: Volume: Page:326-343
ISSN:
Container-title:Exploration of Digestive Diseases
language:en
Short-container-title:Explor Dig Dis

Author:

McCoullough Laura C.¹^ORCID,Littlejohn Margaret²^ORCID,Revill Peter A.²^ORCID

Affiliation:

1. Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia

2. Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia

Abstract

Chronic hepatitis B (CHB) disease caused by persistent infection with hepatitis B virus (HBV) is a global health problem affecting almost 300 million people worldwide, resulting in up to 1 million deaths each year. The factors contributing to HBV mediated liver disease are yet to be fully resolved, however, multiple studies have suggested that HBV splice variants may be a contributing factor. Recent studies have indicated that novel fusion proteins encoded by splice variants, or the splice-derived RNA itself, may impact replication of wild-type HBV, although the direct mechanisms for these interactions are largely unknown. This review explores the latest knowledge regarding the contribution of splice variants to liver disease and their impact on HBV replication.

Funder

National Health and Medical Research Council

Publisher

Open Exploration Publishing

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