Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma-Reference-Cited by-同舟云学术

Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma

Published:2024-09-13 Issue: Volume: Page:567-582
ISSN:
Container-title:Exploration of Drug Science
language:
Short-container-title:Explor Drug Sci

Author:

Soumya Sasikumar Jalajakumari¹,Arya Kesavan Rathi¹^ORCID,Abhinand Chandran Sheela²^ORCID,Sunitha Padmanabhan¹^ORCID,Athira Ajitha Prabhakaran³,Nair Achuthsankar Sukumaran¹,Oommen Oommen V.¹,Sudhakaran Perumana R.¹^ORCID

Affiliation:

1. Department of Computational Biology and Bioinformatics, University of Kerala, Thiruvananthapuram 695581, Kerala, India

2. Department of Computational Biology and Bioinformatics, University of Kerala, Thiruvananthapuram 695581, Kerala, India; Center for Systems Biology and Molecular Medicine, Yenepoya Research Center, Yenepoya (Deemed to be University), Mangalore 575018, Karnataka, India

3. Department of Biochemistry, University of Kerala, Thiruvananthapuram 695581, Kerala, India; Department of Viral Vaccines, Institute of Advanced Virology, Thiruvananthapuram 695317, Kerala, India

Abstract

Glioblastoma (GBM) remains a formidable challenge in neuro-oncology due to its aggressive nature and propensity for therapeutic resistance. Anti-vascular endothelial growth factor (VEGF) therapies, although promising, often encounter resistance that limits their clinical efficacy. A multi-target and multi-drug approach has emerged as compelling strategies to address this resistance to enhance the treatment outcomes. This review examines the complex environment of anti-VEGF resistant GBM and analyses a multi-target therapeutic approach using natural products.

Funder

Kerala State Council for Science, Technology and Environment

Publisher

Open Exploration Publishing

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