Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment-Reference-Cited by-同舟云学术

Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment

Published:2023-02-27 Issue: Volume: Page:18-30
ISSN:
Container-title:Exploration of Drug Science
language:
Short-container-title:Explor Drug Sci

Author:

Ouyang Yi¹,Chen Yan¹,Xu Ting¹,Sun Yihao¹,Zhao Sheng¹,Chen Chunmei¹,Tan Yixin¹,He Liang¹,Liu Hui¹^ORCID

Affiliation:

1. Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Chongqing 400715, China

Abstract

Aim: The development of a collaborative strategy with improved efficacy holds great promise in tumor treatment. This study aims to develop an effective collaborative strategy based on functionalized mesoporous polydopamine (MPDA) nanocomposites for killing tumor cells. Methods: MPDA nanoparticles were synthesized and functionalized with camptothecin (CPT) payload and manganese dioxide (MnO2) coating to construct MPDA-CPT-MnO2 nanocomposites. Results: When uptaken by tumor cells, the nanocomposites can degrade to produce O2, release CPT, and generate manganese (Mn2+) under the stimulation of hydrogen peroxide (H2O2) and acid. The released CPT and Mn2+ can act as chemotherapeutic drug and Fenton-like agent, respectively. Abundant reactive oxygen species (ROS) are generated in 4T1 tumor cells through an Mn2+-mediated Fenton-like reaction. After that, the generated Mn4+ can react with glutathione (GSH) through redox reaction to produce Mn2+ and deplete GSH, disrupting the reducing capacity and benefiting the production of ROS in tumor cells. Under laser irradiation, the nanocomposites can generate hyperthermia to promote the production of ROS. Conclusions: The developed MPDA-CPT-MnO2 nanocomposites can kill tumor cells through collaborative chemo/photothermal/chemodynamic therapy (CDT).

Funder

National Natural Science Foundation of China

Publisher

Open Exploration Publishing

Subject

Polymers and Plastics,Chemical Engineering (miscellaneous),General Engineering,General Materials Science,Electrical and Electronic Engineering,Materials Chemistry,Polymers and Plastics,Biomedical Engineering,Renewable Energy, Sustainability and the Environment,General Chemistry,Electronic, Optical and Magnetic Materials,Materials Chemistry,Polymers and Plastics,Materials Chemistry,Polymers and Plastics,Ceramics and Composites,Materials Chemistry,Polymers and Plastics,General Chemistry,Polymers and Plastics,General Chemical Engineering,General Chemistry,General Engineering,Polymers and Plastics,Organic Chemistry

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