A rare case of tuberculosis-induced hypercalcemia-Reference-Cited by-同舟云学术

A rare case of tuberculosis-induced hypercalcemia

Published:2020-10-12 Issue:3 Volume:30 Page:471-474
ISSN:1846-7482
Container-title:Biochemia medica
language:
Short-container-title:Biochem. med. (Online)

Author:

Wauthier Loris¹,Theunssens Xavier²,Durez Patrick³,Fillée Catherine¹,Maisin Diane¹,Gruson Damien⁴

Affiliation:

1. Department of Clinical Biochemistry, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium

2. Department of Rheumatology, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium

3. Department of Rheumatology, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium; Pôle de Pathologies rhumatismales, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium

4. Department of Clinical Biochemistry, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium; Pôle de recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitai

Abstract

Laboratory investigations of hypercalcemia involve testing of various biochemical parameters such as parathyroid hormone (PTH), 25-(OH) Vitamin D (25-(OH) VitD), 1,25-(OH)2 Vitamin D3 (calcitriol) and PTH related peptide (PTHrp). We herein present an atypical case of severe hypercalcemia in a patient with rheumatoid arthritis who has been treated for years by various biological disease-modifying antirheumatic drugs (DMARDs) and suddenly presented with general state alteration, oedema and ulceration of her right ankle. We illustrate how tuberculosis (TB) can cause high calcitriol concentration and subsequently lead to potentially severe hypercalcemia. Moreover, we highlight the importance of TB testing and follow-up in patients treated with biological DMARDs.

Publisher

Croatian Society for Medical Biochemistry and Laboratory Medicine

Subject

Biochemistry, medical,Clinical Biochemistry

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