Ethics assessment in research proposals adopting CRISPR technology

Author:

Hirsch Francois1,Iphofen Ron2ORCID,Koporc Zvonimir3ORCID

Affiliation:

1. Ethics Committee of the French National Institute of Health and Medical Research (INSERM), Paris, France

2. Independent Research Consultant, La Rochelle, France

3. Catholic University of Croatia, Zagreb, Croatia

Abstract

The rapid and exponential growth of genome editing has posed many challenges for bioethics. This article briefly explains the nature of the technique and the particularly rapid development of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) technology. The international and, specifically, European-level systems for assessing the ethical issues consequent on these developments are outlined and discussed. The challenges posed by cases in China are summarized to raise concerns about how a more shared, universally consistent appraisal of bioethical issues can be promoted.

Publisher

Croatian Society for Medical Biochemistry and Laboratory Medicine

Subject

Biochemistry (medical),Clinical Biochemistry

Reference39 articles.

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2. Targeted genome editing across species using ZFNs and TALENs.;Wood;Science,2011

3. ClinicalTrials.gov. Available at: https://clinicaltrials.gov/ct2/results?cond=&term=genome+editing&cntry=&state=&city=&dist=&Search=Search. Accessed April 4th 2019.

4. On the origin of CRISPR-Cas Technology: From prokaryotes to mammals.;Mojica;Trends Microbiol,2016

5. Genome editing. The new frontier of genome engineering with CRISPR-Cas9.;Doudna;Science,2014

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