Laboratory policies and practices for thyroid function tests in Croatia: survey on behalf of Working Group for Laboratory Endocrinology of the Croatian Society of Medical Biochemistry and Laboratory Medicine

Author:

Siter Kuprešanin Marija1,Đuras Anamarija2,Leniček Krleža Jasna3,Pezo Alenka4,Lukić Iva5,Bokulić Adriana6,Zec Ivana6,Goreta Sanja6,Nikolac Gabaj Nora7,Kocijančić Marija8,Serdar Hiršl Tihana9,Troha Mateja10,Stanišić Lada11,Šupe-Domić Daniela11,Jelisavac Ćosić Sanda12,Đurić Koraljka13,Marijančević Domagoj6

Affiliation:

1. Department of Medical Laboratory Diagnostics, University Hospital Sveti Duh, Zagreb, Croatia

2. Department of Medical Biochemistry Laboratory, General Hospital Varaždin, Varaždin, Croatia

3. Croatian Society of Medical Biochemistry and Laboratory Medicine (CROQALM), Zagreb, Croatia

4. Medical Biochemistry Laboratory, Primary Health Care Centre Zagreb - East, Zagreb, Croatia

5. Department for Clinical Laboratory Diagnostics, University Hospital Centre Osijek, Osijek, Croatia

6. Laboratory of Endocrinology, Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia

7. University Department of Chemistry, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia

8. Central Laboratory, University Hospital Halle, Halle (Saale), Germany

9. Medical Biochemistry Laboratory, Synlab Hrvatska-Polyclinic for Medical Laboratory Diagnostics, Zagreb, Croatia

10. Department of Laboratory Diagnostics, General Hospital Dr. Josip Benčević, Slavonski Brod, Croatia

11. Department of Medical Laboratory Diagnostics, University Hospital of Split, Split, Croatia

12. Department of Nuclear Medicine and Radiation Protection, University Hospital Centre Zagreb, Zagreb, Croatia

13. Medical Biochemistry Laboratory, Special Hospital AGRAM, Zagreb, Croatia

Abstract

IntroductionLaboratory plays important part in screening, diagnosis, and management of thyroid disorders. The aim of this study was to estimate current laboratory preanalytical, analytical and postanalytical practices and policies in Croatia. Materials and methodsWorking Group for Laboratory Endocrinology of the Croatian Society of Medical Biochemistry and Laboratory Medicine designed a questionnaire with 27 questions and statements regarding practices and protocols in measuring thyroid function tests. The survey was sent to 111 medical biochemistry laboratories participating in external quality assurance scheme for thyroid hormones organized by Croatian Centre for Quality Assessment in Laboratory Medicine. Data is presented as absolute numbers and proportions. ResultsFifty-three participants returned the questionnaire. Response rate varied depending on question, yielding a total survey response rate of 46-48%. All respondents perform thyroid stimulating hormone (TSH). From all other thyroid tests, most performed is free thyroxine (37/53) and least TSH-stimulating immunoglobulin (1/53). Laboratories are using nine different immunoassay methods. One tenth of laboratories is verifying manufacturer’s declared limit of quantification for TSH and one third is verifying implemented reference intervals for all performed tests. Most of laboratories (91%) adopt the manufacturer’s reference interval for adult population. Reference intervals for TSH are reported with different percentiles (90, 95 or 99 percentiles). ConclusionThis survey showed current practices and policies in Croatian laboratories regarding thyroid testing. The results identified some critical spots and will serve as a foundation in creating national guidelines in order to harmonize laboratory procedures in thyroid testing in Croatia.

Publisher

Croatian Society for Medical Biochemistry and Laboratory Medicine

Subject

Biochemistry (medical),Clinical Biochemistry

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