Author:
Nagaoka Satoshi,Miyazaki Hitoshi,Aoyama Yoritaka,Yoshida Akira
Abstract
Dietary polychlorinated biphenyls (PCBs) caused hypercholesterolaemia in rats. The concentration and output of biliary cholesterol was significantly lower than that of the control group. Biliary output of total bile acids was significantly decreased in rats given the PCB-supplemented diet. Faecal excretion of total steroids (sum of neutral steroids and acidic steroids) was not significantly changed in rats given the PCB-supplemented diet. The present results indicate that dietary PCBs cause hypercholesterolaemia without modifying the faecal total steroids excretion. These results suggest that PCBs produce hyper-cholesterolaemia accompanied by changes in biliary or faecal excretion of bile acids and neutral steroids in addition to an increase in hepatic cholesterol synthesis.
Publisher
Cambridge University Press (CUP)
Subject
Nutrition and Dietetics,Medicine (miscellaneous)
Reference36 articles.
1. Influence of Chronic Ascorbic Acid Deficiency and Excessive Ascorbic Acid Intake on Bile Acid Metabolism and Bile Composition in the Guinea Pig
2. Amino Acid Balance and Imbalance
3. Age-related changes in cholesterol and bile acid metabolism in rats;Uchida;Journal of Lipid Research,1978
4. Metabolic studies on polychlorinated biphenyls. V. Biliary excretion of 5-hydroxy-2, 4, 3',4'-tetrachlorobiphenyl, a major metabolite of 2, 4, 3',4'-tetrachloro-biphenyl;Yoshimura;Fukuoka Acta Medicine,1974
5. Mechanisms of bile formation, hepatic uptake, and biliary excretion;Klassen;Pharmacological Review,1984
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献