Jejunal absorption of an amino acid mixture simulating casein and an enzymic hydrolysate of casein prepared for oral administration to normal adults

Author:

Silk D. B. A.,Clark M. L.,Marrs T. C.,Addison Jill M.,Burston D.,Matthews D. M.,Clegg K. Mary

Abstract

1. An intestinal perfusion technique was used in six normal human subjects to study absorption of sixteen individual amino acids from an amino acid mixture simulating casein and from an enzymic hydrolysate of casein, prepared for oral administration to these subjects, which consisted of a mixture of oligopeptides and free amino acids.2. Total absorption of α-amino nitrogen was greater from the casein hydrolysate than from the amino acid mixture, and the considerable variation in percentage absorption of individual amino acids from the amino acid mixture was much reduced when the enzymic hydrolysate solution was perfused, as a number of amino acids which were poorly absorbed from the amino acid mixture were absorbed to a greater extent from the casein hydrolysate.3. These findings indicate that after extensive intestinal resections or in malabsorption there might be significant nutritional advantages in the administration of protein hydrolysates rather than amino acid mixtures.

Publisher

Cambridge University Press (CUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

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1. The Effect of a Compound Protein on Wound Healing and Nutritional Status;Evidence-Based Complementary and Alternative Medicine;2022-03-24

2. Gastric digestion of protein through pancreozyme action optimizes intestinal forms for absorption, mucin formation and villus integrity;Animal Feed Science and Technology;2016-11

3. Whey protein hydrolysates enhance water absorption in the perfused small intestine of anesthetized rats;Bioscience, Biotechnology, and Biochemistry;2016-08-02

4. Amino Acid and Peptide Absorption in Man;Ciba Foundation Symposium 50 - Peptide Transport and Hydrolysis;2008-05-30

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