Author:
Powers Hilary J.,Weaver Lawrence T.,Austin Steven,Beresford John K.
Abstract
The effect of riboflavin deficiency on gastrointestinal Fe distribution and loss was studied in weanling rats. Riboflavin deficiency was associated with a significant increase in crypt depth in the upper and mid small intestine and a twofold increase in the rate of crypt cell production compared with weight-matched andad lih.-fed control rats. The rate of loss of endogenous Fe, measured as faecal59Fe after intraperitoneally administered59Fe, was twice that from riboflavin-deficient rats compared with weightmatched controls. We suggest that while there may be a contribution from turnover of enterocytes with an enhanced Fe content, enhanced Fe loss associated with riboflavin deficiency is due predominantly to an accelerated rate of small-intestinal epithelial turnover.
Publisher
Cambridge University Press (CUP)
Subject
Nutrition and Dietetics,Medicine (miscellaneous)
Reference13 articles.
1. A Study of Maternofetal Iron Transfer in the Riboflavin-Deficient Rat
2. Effects of riboflavin deficiency in rats on some aspects of iron metabolism;Powers;International Journul of Vitamin and Nutrition Re.search,1983
3. The effects of riboflavin administration on iron metabolism parameters in a school-going population;Buzina;International Journal of Vitamin and Nutrition Research,1979
4. Riboflavin deficiency in the rat: effects on iron utilization and loss
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