Abstract
This chapter reviews literature data on the prevalence, risk factors, diagnosis, physiopathology, treatment, and prevention of home parenteral nutrition (HPN)-related liver disease. Available evidence shows that HPN-associated liver disease is related to both the HPN regimen and underlying disease. Therapy includes, besides optimization of the nutritional regimen: (i) the use of ursodeoxycholic acid, taurine and α-tocopherol supplementation; (ii) short-term antibiotic cover; (iii) re-establishment of colon continuity; and (iv) implementation of enteral feeding.