Abstract
This chapter focuses on spatial patterns of malaria, especially those of altitudinal shifts, with climate change, emphasizing the need to consider the effect of warmer temperatures on the disease from a regional context rather than a global one. The malaria climate suitability and biogeographically based climate change impact assessment in Africa and the estimation of Ethiopia's climate change burden using the malaria lapse rate are described. The spatial issues of warming at the cool (in the highlands, that is the highly populated) tail of the malaria distribution are addressed.