Author:
Kaput Jim,Ordovas Jose M.,Ferguson Lynnette,van Ommen Ben,Rodriguez Raymond L.,Allen Lindsay,Ames Bruce N.,Dawson Kevin,German Bruce,Krauss Ronald,Malyj Wasyl,Archer Michael C.,Barnes Stephen,Bartholomew Amelia,Birk Ruth,van Bladeren Peter,Bradford Kent J.,Brown Kenneth H.,Caetano Rosane,Castle David,Chadwick Ruth,Clarke Stephen,Clément Karine,Cooney Craig A.,Corella Dolores,da Cruz Ivana Beatrice Manica,Daniel Hannelore,Duster Troy,Ebbesson Sven O. E.,Elliott Ruan,Fairweather-Tait Susan,Felton Jim,Fenech Michael,Finley John W.,Fogg-Johnson Nancy,Gill-Garrison Rosalynn,Gibney Michael J.,Gillies Peter J.,Gustafsson Jan-Ake,Hartman John L.,He Lin,Hwang Jae-Kwan,Jais Jean-Philippe,Jang Yangsoo,Joost Hans,Junien Claudine,Kanter Mitchell,Kibbe Warren A.,Koletzko Berthold,Korf Bruce R.,Kornman Kenneth,Krempin David W.,Langin Dominique,Lauren Denis R.,Lee Jong Ho,Leveille Gilbert A.,Lin Su-Ju,Mathers John,Mayne Michael,McNabb Warren,Milner John A.,Morgan Peter,Muller Michael,Nikolsky Yuri,van der Ouderaa Frans,Park Taesun,Pensel Norma,Perez-Jimenez Francisco,Poutanen Kaisa,Roberts Matthew,Saris Wim H.M.,Schuster Gertrud,Shelling Andrew N.,Simopoulos Artemis P.,Southon Sue,Tai E. Shyong,Towne Bradford,Trayhurn Paul,Uauy Ricardo,Visek Willard J.,Warden Craig,Weiss Rick,Wiencke John,Winkler Jack,Wolff George L.,Zhao-Wilson Xi,Zucker Jean-Daniel
Abstract
Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.
Publisher
Cambridge University Press (CUP)
Subject
Nutrition and Dietetics,Medicine (miscellaneous)