Effect of tunicamycins on GlcNAc-1-P transferase activity in rat tissues and toxic effects during pregnancy and lactation.

Abstract

This study evaluates the inhibition of N-acetylglucosamine-1-phosphate transferase (GPT) from different tissue sources within exposed rats, the potential for corynetoxins (CTs) and tunicamycins (TMs) to transfer to the mammary gland, contaminate milk and adversely affect the nursling, and the toxic effects on the pregnant rat and on the developing fetuses. Liver rough microsomal GPT is the most sensitive indicator of in vitro exposure to TMs.