AbstractThis review covers: developmental choice for Strongyloides ratti; diversity and artificial selection for developmental route; the environment and developmental route; phenotypic plasticity in response to temperature; the molecular basis of variation in sensitivity; developmental route and host immunity; interaction of host immunity and temperature on developmental route; phenotypic diversity and arrested development; phenotypic diversity and immunology; parasite modulation of host immune responses; the consequences of laboratory maintenance on parasitic nematodes.