Author:
Bunyan J.,Green J.,Diplock A. T.,Robinson D.
Abstract
1. Activities of β-glucuronidase, β-galactosidase, acid phosphatase and cathepsin were measured in the uterine contents of normal rats during gestation and of vitamin E-deficient rats during foetal resorption.2. β-Glucuronidase activity reached a peak value on days 11 and 12, falling to lower values by day 14. Deficient rats showed slightly greater mean values than normal rats on days 11 and 12, but not after that time.3. Vitamin E deficiency did not affect the activities of β-galactosidase, acid phosphatase and cathepsin, all of which showed a slow decrease during pregnancy.4. The supernatant fraction of homogenates of uterine contents from deficient rats showed increased β-glucuronidase and β-galactosidase activity from day 14 to 17, suggesting some degree of rupture of the lysosomal membrane.5. β-Glucuronidase and acid phosphatase activities were raised in the uteruses of some deficient rats towards the end of pregnancy, but serum β-glucuronidase was unaffected.6. Changes in lysosomal hydrolases were not so marked during gestation–resorption as in some other vitamin E deficiency states, such as muscular dystrophy in the chick and rabbit.
Publisher
Cambridge University Press (CUP)
Subject
Nutrition and Dietetics,Medicine (miscellaneous)
Cited by
17 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献