AbstractThis chapter describes the general agricultural context of Ethiopia, the characteristics of seven agroecological zones, the soil types, and the main cropping. It addresses fertilizer use optimization in Ethiopia and factors that affect profitability of fertilizer use. Computer-run and paper-based decision tools are introduced for optimizing fertilizer use giving choices expected to maximize profit to fertilizer use. Also, a tool for adjusting fertilizer rates according to practices such as manure use and according to soil test information is provided. A comparison is made of current fertilizer rate recommendations with the rates that are expected to maximize net returns per hectare due to fertilizer use, called in this chapter the economically optimal rates of nutrient application.