Author:
Hinds Alison,Sanders T. A. B.
Abstract
The influence of increasing intakes of fish oil on spleen leucocyte phospholipid fatty acid composition and cell-mediated immunity was studied in the mouse using a popliteal lymph node assay technique. The immune response was suppressed by 160 g fish oil/kg diet, but not by lower doses. The proportion of 20: 5n-3 in spleen leucocyte phospholipid increased from 0.14 in the controls to 3.8, 7.2, 8.5 and 9.4% in the animals fed on 25, 50, 100 and 160 g fish oil/kg diet; the proportion of 22: 6n-3 increased from 5.1 in the controls to 12.1, 12.2, 12.8 and 12.9% respectively. It is concluded that moderate intakes of fish oil are not immunosuppressive.
Publisher
Cambridge University Press (CUP)
Subject
Nutrition and Dietetics,Medicine (miscellaneous)
Reference20 articles.
1. Omega-6 and omega-3 polyunsaturates and the immune system.;Mertin;British Journal of Clinical Practice,1983
2. Essential andTrans-Fatty Acids in Nutrition
3. Effect of increasing levels of dietary eicosapentaenoic (20: 5n-3) and docosahexaenoic (22: 6n-3) acids on lymphocyte phospholipid composition and cell-mediated immunity in the mouse.;Hinds;Proceedings of the Nutrition Society,1986
4. Influence of dietary eicosapentaenoic (20: 5n-3) and docosapentaenoic (22: 6n-3) acids on cell-mediated immunity in the mouse.;Sanders;Proceedings of the Nutrition Society,1985
5. Prostaglandin precursors and the cell-mediated immune response
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