Technique for In-vitro Evaluation of Release of Antibiotics into Milk from Carrier Vehicle1

Abstract

An apparatus to determine the rate of release of chemotherapeutics from vehicles was developed. It consists of a semi-permeable chamber within a larger glass chamber. The semi-permeable chamber has direct contact with milk within the glass chamber. Preliminary evaluation for rapidity of release of chemotherapeutics by vehicles, in decreasing amount of antibiotic released, showed them to be water, sesame oil, sweet cream butter, peanut oil with aluminum monostearate, lanolin and petrolatum.