Mycobacterium tuberculosis Infection in a Domesticated Korean Wild Boar (Sus scrofa coreanus)

Author:

Seo Min-Goo1,Ouh In-Ohk1,Kim Munki2,Lee Jienny1,Kim Young-Hoan3,Do Jae-Cheul3,Kwak Dongmi4

Affiliation:

1. Animal and Plant Quarantine Agency, Gimcheon 39660, Korea;

2. Pohang Center for Evaluation of Biomaterials, Pohang Technopark, Pohang 37668, Korea;

3. Gyeongbuk Veterinary Service Laboratory, Daegu 41405, Korea; and

4. College of Veterinary Medicine and Cardiovascular Research Institute, Kyungpook National University, Daegu 41566, Korea (ORCID: http://orcid.org/0000-0003-0876-3179)

Abstract

ABSTRACTTuberculosis, a chronic progressive disease, has been reported in bovine, swine, and primate species. Here, we report the first case of Mycobacterium tuberculosis infection in a Korean wild boar (Sus scrofa coreanus). The owners this domesticated boar brought it to the Gyeongbuk Veterinary Service Laboratory in Korea after it was found dead and severely emaciated. Demarcated yellowish white nodules were found around the larynx and retropharyngeal lymph node during necropsy. The lungs had diffuse fibrinous pleuritis, severe congestion, and scattered nodules. More nodules were found in the spleen. Tuberculosis is characterized by massive macrophage infiltration and central caseous necrosis; both characteristics were found in the lungs. Histopathologic examination revealed that the alveolar lumen had marked fibrosis and exudates. Examination of the fluid revealed extensive macrophage permeation. To confirm a Mycobacterium infection, PCR was performed using two primer sets specific to the rpoB gene of Mycobacterium; Mycobacterium was detected in the lungs and spleen. To identify the species of Mycobacterium, immunohistochemical evaluation was performed using antibodies against Mycobacterium tuberculosis and Mycobacterium bovis. The results revealed immunoreactivity against M. tuberculosis but not against M. bovis. The consumption of undercooked or raw meat from game animals may expose humans and other animals to sylvatic infection. Consequently, Koreans who ingest wild boar may be at risk of a tuberculosis infection. To reduce the risk of foodborne infection and maintain public health, continuous monitoring and control strategies are required.

Publisher

International Association for Food Protection

Subject

Microbiology,Food Science

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Wild Boar: A Reservoir of Foodborne Zoonoses;Foodborne Pathogens and Disease;2019-03

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