Affiliation:
1. Chita State Medical Academy
Abstract
Aim. To study lymphocytic-platelet adhesion, eosinophils and IgE concentration in children with acute obstructive bronchitis. Materials and methods. 70 children were examined, the first group consisted of children with acute bronchitis (n=38), the second group included healthy children (n=32). All children were examined for the concentration of IgE, the number of lymphocytes and eosinophils, and the count of lymphocyte-platelet aggregates. Results. In patients with obstructive bronchitis, there was no difference in the concentration of the relative and absolute number of lymphocytes compared with healthy children. High values of eosinophils were found in children with obstructive bronchitis (9.0 ± 0.7 %) while in children of the control group the same indicator was determined within the limits of normal values (0.9 ± 0.2 %). The level of IgE in children with obstructive bronchitis exceeded the concentration of this indicator in healthy children by 19 times. In children with obstructive bronchitis, the index and degree of lymphocyticplatelet adhesion were 20.0 ± 0.7 % and 10.5 ± 0.09, respectively, statistically significantly higher than similar indices in healthy children (14.0 ± 0.2 %, p = 0.0001 and 3.3 ± 0.1, p = 0.001, respectively). Conclusion. In the body of children with obstructive bronchitis, an immune response develops, which is involved in the pathogenesis of recurrence of the disease, the causes of which are infectious agents that stimulate innate immunity due to the presentation of PAMP molecules, as well as adaptive immunity, accompanied by killer reactions, the production of immunoglobulins, including IgE.
Publisher
Far Eastern Scientific Center Of Physiology and Pathology of Respiration
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