Affiliation:
1. Research Institute for Medical Problems in the North Division of Federal Research Center «Krasnoyarsk Scientific Center of the Siberian Branch of the RAS»
Abstract
Introduction. Chronic rhinitis is one of the common ENT diseases characterized by nasal congestion, leading to intermittent hypoxia and, consequently, to a disturbance in the balance of prooxidants and antioxidants in the blood plasma, which may reduce the quality of life of patients.Aim. To evaluate the impact of the "lipid peroxidation – antioxidant defense" system indicators on the quality of life of patients with chronic rhinitis of different phenotypes, using the SNOT-22 disease outcome assessment test.Materials and methods. The study groups included 45 patients with chronic allergic rhinitis, 49 patients with chronic vasomotor rhinitis, 32 patients with chronic atrophic rhinitis, 39 patients with chronic infectious rhinitis, and 40 individuals in the control group. Spectrophotometric method in blood plasma determined the indicators of the "lipid peroxidation – antioxidant defense" (LPO-AOD) system: diene conjugates, malondialdehyde, catalase, superoxide dismutase, ceruloplasmin, reduced glutathione, glutathione-S-transferase, glutathione peroxidase, and surveyed using the Russian version of the SNOT-22 questionnaire.Results. For all patients from the study groups with chronic rhinitis, a decrease in the concentration of antioxidant system components was characteristic. An increase in lipid peroxidation was found in chronic allergic, atrophic, and infectious rhinitis, with the most significant disturbance detected in chronic infectious rhinitis. A total of the highest number of disturbances in the LPO-AOD system was found in patients from the study groups with chronic infectious rhinitis – 7, with chronic atrophic rhinitis – 6, with chronic allergic rhinitis – 5, with chronic vasomotor rhinitis – 3. Patients with chronic rhinitis showed a decrease in quality of life across all compared indicators: physical (in all groups) and psychological (in chronic atrophic rhinitis) health components were impaired. A direct correlation (r=0.83; p=0.001) was established between the quality of life and the number of disturbances in the LPO-AOD system, with the most significant decrease in quality of life found in patients from the study groups with chronic infectious rhinitis with the maximum imbalance in the LPO-AOD system.Conclusion. The quality of life of patients is an important health indicator that depends on the disease phenotype and the performance of the LPO-AOD system. Identifying potential mechanisms for the formation of quality of life as an indicator with a predominantly subjective character under the conditions of an objectively existing disease presents a promising approach for defining measures aimed at improving the quality of life.
Publisher
Far Eastern Scientific Center Of Physiology and Pathology of Respiration
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