Affiliation:
1. Khabarovsk Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Maternity and Childhood Protection
2. Khabarovsk Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Maternity and Childhood Protection;
Far Eastern State Medical University
Abstract
Glutathione S-transferase superfamily genes (GSTT1, GSTM1) encode phase II detoxification system enzymes; their mutations increase the sensitivity of the organism to the impact of damaging factors and the development of various diseases. Objective: to present the ecological and ethnic features of the distribution of polymorphic variants of these genes based on the analysis of domestic and foreign literature. The article describes the functional effects of genetic polymorphisms and shows the different frequency of polymorphic variants of GSTM1 and GSTT1 genes depending on race in Russia and the world. Special attention is given to the prevalence features of detoxification gene polymorphisms among the indigenous and migrant populations of the Amur region. Based on the literature data analysis, the conclusion is made about the importance of considering ethnic background, living conditions, and the state of "predisposition" genes for developing a personalized approach to prediction, prevention, and treatment.
Publisher
Far Eastern Scientific Center Of Physiology and Pathology of Respiration
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