Affiliation:
1. Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Medical Climatology and Rehabilitative Treatment
Abstract
Inroduction. The assessment of the respiratory system is of particular importance in the context of increasing impact of anthropogenic factors on human health. Aim. Evaluation the response of the lung function indices to the effects of micro-suspensions and toxic metals in patients with chronic obstructive pulmonary disease (COPD), using regression models. Materials and methods. The study involved 60 patients with stable mild-to-moderate COPD and 30 healthy people (the control group). The analysis of lung function was carried out by spirometry and body plethysmography. Arterial oxygen saturation (SaO2 ) was measured by pulse oximetry. Exhaled CO2 concentration and blood carboxyhemoglobin (COHb%) concentration were assessed using a portable analyzer MicroCO Meter. The pollution of the city atmosphere was assessed by aerosol suspensions of solid particles in the areas of residence of the examined patients. Fractional composition of suspended particles (0-1, 1-10, 10-50, 50-100, 100-400, 400-700,> 700 μm; %) were analyzed in the areas of residence of the examined patients. Toxic metal (Pb, Cr, Mn, Fe, Co, Ni, Cu, Zn; μg/L) levels in the air samples were determined. The statistical module "Multiple regression" was used for assessing the response of functional parameters of the respiratory system. Results. The analysis of one-factor and multi-factor regression models made it possible to identify both trigger factors of dust and technogenic air pollution and the synergistic effect of the influence of dominant factors. It has been shown that multifactorial reactions to technogenic impact manifest as altered blood oxygen saturation and carboxyhemoglobin level and thereby contribute to the development of respiratory failure. Conclusion. Patients with COPD exhibited increased bronchial resistance to the effect of the trigger factor (Pb – 1 hazard class) associated with high motorization of the city. The response of pulmonary gas exchange (SaO2 ) to Pb in the control group indicates prolonged exposure to toxic metals can cause developing respiratory failure even in the healthy population of the city.
Publisher
Far Eastern Scientific Center Of Physiology and Pathology of Respiration
Reference20 articles.
1. Arkhipov V.A., Sheremet'eva U.М. Aerosol systems and their impact on vital activity. Tomsk: Tomsk State Pedagogical University; 2007 (in Russian).
2. Veremchuk L.V., Yan'kova V.I., Vitkina T.I., Barskova L.S., Golokhvast K.S. The delopment of atmospheric air pollution in city and its impact on respiratory morbidity. Sibirskiy nauchnyy meditsinskiy zhurnal = Siberian Scientific Medical Journal 2015; 35(4):55–61 (in Russian). Available at: https://www.elibrary.ru/item.asp?id=24038836
3. Veremchuk L.V., Yan'kova V.I., Vitkina T.I., Golokhvast K.S., Barskova L.S. The atmospheric pollution in urbanized territories as a system process of the interaction of environmental factors. Zdorov'e. Meditsinskaya ekologiya. Nauka = Health. Medical Ecology. Science 2015; (3):35–42 (in Russian). Available at: https://www.elibrary.ru/item.asp?id=23754629
4. Kamarehie B., Ghaderpoori M., Jafari A., Karami M., Mohammadi A., Azarshab K. Ghaderpoury A., Noorizadeh N. Estimation of health effects (morbidity and mortality) attributed to PM10 and PM2.5 exposure using an Air Quality model in Bukan city, from 2015-2016 exposure using air quality model. Environ. Health Eng. Manag. J. 2017; 4(3):137–142. https://doi.org/10.15171/EHEM.2017.19
5. Paulin L., Hansel N. Particulate air pollution and impaired lung function. F1000Research 2016, 5(F1000 Faculty Rev):201. https://doi.org/10.12688/f1000research.7108.1