The effect of cyclic polychemotherapy on the morphofunctional state of the gonads

Abstract

Aim. The analysis of scientific publications on the treatment of malignant neoplasms, the effect of antitumor therapy on the morphofunctional state of the gonads is carried out.Results. Treatment of malignant neoplasms is often accompanied by side effects that directly depend on the patient’s age, type of cancer, treatment regimen and doses, which has put forward a new urgent problem – the state of health and quality of life during remission of cancer or after recovery from it. Thus, cytostatically induced testicular damage leads to reproductive dysfunction in men on the “pre-testicular” (central nervous system and the peripheral nervous system, pituitary gland), “testicular” (gonads), “post-testicular” (epididymis, etc. organs of the genitourinary system involved in spermogenesis) levels of the reproductive system, which is especially important against the background of a sharply declining fertility of the modern male population. Accordingly, understanding the regularities of the processes of reparative regeneration of damaged tissues is important for the development of rehabilitation programs, the preservation of reproductive function and quality of life in patients who have undergone cytostatic therapy, especially in young people.Conclusion. The literature review covers epidemiological and experimental data on the effects of chemotherapy on spermatogenesis.