Effects of Chromosomal Translocations on Sperm Count in Azoospermic and Oligospermic Cases-Reference-Cited by-同舟云学术

Effects of Chromosomal Translocations on Sperm Count in Azoospermic and Oligospermic Cases

Published:2022-09-08 Issue: Volume: Page:
ISSN:2458-8938
Container-title:Journal of Basic and Clinical Health Sciences
language:en
Short-container-title:JBACHS

Author:

AYAZ Akif¹,YALÇINTEPE Sinem²,ÖZALP YÜREĞİR Özge³,YILMAZ GÜLEÇ Elif⁴,GEZDİRİCİ Alper⁵,PERİM AKÇAY Ebru⁶,KÖSEOĞLU Abdullah Hüseyin⁶,ŞAHİN Yavuz⁷

Affiliation:

1. ISTANBUL MEDIPOL UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF MEDICAL GENETICS (MEDICINE)

2. TRAKYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF MEDICAL GENETICS

3. UNIVERSITY OF HEALTH SCIENCES, ADANA NUMUNE HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF MEDICAL GENETICS

4. ISTANBUL MEDENIYET UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF MEDICAL GENETICS

5. SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAŞAKŞEHİR ÇAM VE SAKURA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ GENETİK ANABİLİM DALI

6. ISTANBUL MEDIPOL UNIVERSITY GENETIC DISEASES ASSESSMENT CENTER

7. GENOKS GENETIC DISEASES DIAGNOSIS CENTER

Abstract

Purpose A number of mechanisms have been proposed for the effect of chromosomal translocations on spermatogenesis and sperm maturation. However, there are still numerous ambiguous issues regarding these two processes. The aim of this study is to evaluate the effect of chromosome break areas on sperm count in the light of the literature. Material and Methods The study was conducted on the data of 16 male patients with reciprocal or Robertsonian translocation among 152 patients who were admitted to Adana Numune Training and Research Hospital and Kanuni Sultan Süleyman Training and Research Hospital Genetic Diagnosis Centers between 2013 and 2016 due to azoospermia and oligospermia. Results 11 of these patients had reciprocal and five patients had Robertsonian translocations. All the patients with Robertsonian translocations were detected with azoospermia. Of the patients with reciprocal translocation, five of them were azoospermic and six of them were severe oligospermic. Conclusion A total of 21 chromosomal breakpoints were identified in the 11 patients with reciprocal translocations. These chromosomal breakpoints may contribute to the clarification of ambiguous issues related to spermatogenesis and sperm maturation. The results also showed the importance of genetic counselling in patients with translocations.

Publisher

Dokuz Eyul Universitesi Saglik Bilimleri Enstitusu

Subject

General Medicine

Reference33 articles.

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