1. From Systematic Investigation and Research on Interventions and Outcomes (SIRIO) MEDICINE Research Network, Collegium Medicum in Bydgoszcz, Dr Antoni Jurasz Memorial University Hospital, and Nicolaus Copernicus University, Bydgoszcz, Poland; University of Nicolaus Copernicus, Torun, Poland; Catholic University, Rome, Italy; University of Bari, Bari, Italy; Inova Heart and Vascular Institute and SIRIO MEDICINE Research Network, Falls Church, Virginia; and George Mason University, Fairfax, Virginia.