Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19-Reference-Cited by-同舟云学术

Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19

Published:2023-05 Issue:5 Volume:176 Page:667-675
ISSN:0003-4819
Container-title:Annals of Internal Medicine
language:en
Short-container-title:Ann Intern Med

Author:

Reis Gilmar¹^ORCID,dos Santos Moreira Silva Eduardo Augusto²^ORCID,Medeiros Silva Daniela Carla²^ORCID,Thabane Lehana³^ORCID,de Souza Campos Vitoria Helena²^ORCID,Ferreira Thiago Santiago⁴,Quirino dos Santos Castilho Vitor²,Ribeiro Nogueira Ana Maria⁵,Figueiredo Guimaraes Almeida Ana Paula⁶,Cançado Monteiro Savassi Leonardo⁷^ORCID,de Figueiredo Neto Adhemar Dias⁸,Bitarães Carina⁹^ORCID,Cruz Milagres Aline⁹,Diniz Callegari Eduardo¹⁰,Campos Simplicio Maria Izabel⁴,Barra Ribeiro Luciene⁴,Oliveira Rosemary⁴,Harari Ofir¹¹,Wilson Lindsay A.¹²,Forrest Jamie I.¹²,Ruton Hinda¹¹^ORCID,Sprague Sheila³,McKay Paula³,Guo Christina M.¹²,Guyatt Gordon H.³^ORCID,Rayner Craig R.¹³,Boulware David R.¹⁴^ORCID,Ezer Nicole¹⁵,Lee Todd C.¹⁶^ORCID,McDonald Emily Gibson¹⁷^ORCID,Bafadhel Mona¹⁸^ORCID,Butler Christopher¹⁹^ORCID,Rodrigues Silva Josue¹²^ORCID,Dybul Mark²⁰^ORCID,Mills Edward J.²¹,Reis Gilmar,dos Santos Moreira Silva Eduardo Augusto,Medeiros Silva Daniela Carla,Quirino dos Santos Castilho Vitor,Ribeiro Nogueira Ana Maria,Figueiredo Guimaraes Almeida Ana Paula,de Figueiredo Neto Adhemar Dias,Cançado Monteiro Savassi Leonardo,Barra Ribeiro Luciene,Campos Simplicio Maria Izabel,Ferreira Thiago Santiago,de Souza Campos Vitoria Helena,Thabane Lehana,Forrest Jamie,Mills Edward J.,Cameron William,Orbinski James,Singh Sonal,Thorlund Kristian,Haggstrom Jonas,Costa Heloísa A.,Drumont Nayara S.,Bessa Stephanny K.,Vieira João V.B.,Campos Vania R,Oliveira Rosemary M,Suterio Lineria HM,Rodrigues Silva Josue,Junior Adelino de melo Freire,Rocha Ana Carolina Fialho Dias,Gonçalves Ana Paula de Faria,França Andressa,Igídio Carlos Eduardo Dias,Sousa Igor César de Oliveira,Carvalho Iracema Luisa Quintino de,Benavides Larissa Maria Manini,Pereira Patrícia de Oliveira,Sousa Phelipy Marques de,Lima Sabrina de Almeida,Pedroso Silvia Helena Sousa Pietra,Resende Snaydia Viegas,Rocha Wellington da Silva,Alves Thamiris Caldeira,Martins Aline Lúcia de Jesus,Mesquita Amanda Gouvêa,Mendes Amanda Larissa Alves,Mendes Anna Beatriz Oliveira,Oliveira Anna Clara de Jesus,Cysne Carolina Couto de Azevedo,Pereira Clara Bensemann Gontijo,Siqueira Cecília Campos,Dias Ednilson Barbosa,Gonçalves Emanuelle Cristina Soares,Guimarães Fernanda Leal,Giorgeto Flávio Eduardo,Rodrigues Gabriel Torga Saade,Sousa Gislânia Neres de,Rezende Júlia Campos de,Moreira Júlia Diniz Assis,Soares Isabela Canabrava,Silveira João Victor Barbosa,Souza Joselaine Gomes de,Ferreira Juliana Marques Santos,Gonçalves Kênia Sthéfhane Guimarães,Oliveira Laura Campos,Almeida Layane Maria de,Siqueira Letícia Campos,Costa Letícia de Fátimas,Maciel Lorena Gabrielle Miranda,Peixoto Lorena Giovanna Silva,Alves Lorena Mesquita,Rodrigues Luana Rosa,Almeida Luisa Andrade de,Lara Marcela Luíza Amaral Resende,Reis Luíza Lanna França,Horácio Maria Eduarda Gomes,Soares Maria Eduarda Martins,Parreiras Maria Luiza Magalhães,Siqueira Mariana Campos,Mariano Mariana Cristina Flores,Bragatto Marina Guimarães,Silva Matheus Andrade Almeida e,Santos Mayra Estefane Silva dos,Ribeiro Mirele Augusta Batista,Drumond Nayara Santos,Guimarães Pedro Hosken Fernandes,Diniz Pollyana Maria Silva,Lopes Roberta Dumont Paiva,Oliveira Rosemary Muniz de,Bessa Stephanny Kelvyn,Anselmo Sheila Soares,Vieira Tainara Silva,Silva Tatiana Aparecida Gomes da,Siqueira Thais Campos,Carmo Vânia Regina,Vale Vitor Augusto Lima do,Oliveira Vitor Vilaça,Santos Wedsley Sander Lopes dos,Abreu Aline Daniele de Almeida,Camargos Bernardo Saraiva Resende de,Heringer Camila Araújo,Filho Daniel Jacinto Mendonça,Abreu Eriane Damasia Faria de Almeida,Barnabé Felipe augusto Pereira,Vieira Felipe Alves,Carvalho Gabriella Fagundes,Mussi Higor Gomes,Macedo Hilton Cardoso Arruda,Caciquinho Igor Bernardes,Santos João Pedro Ribeiro,Costa João Ricardo Garcia,Cardoso José Lauro Guimarães,Abreu Júlia Berlim de,Carvalho Lorena Rodrigues de,Oliveira Lorena Amaral de,Matos Luana Rocha Oliveira,Brito Marcela Ferreira,Silva Mariana Cavaliere Batista e,Rodrigues Matheus Lucca Ângelo Costa,Ferreira Mateus de Oliveira,Perez Murilo Passinati,Zanetti Natalia Batista,Almeida Rafaela Ribeiro de,Jamar Sarah Jeniffer da Silva,Barbosa Sofia Caporalli,Rios Sofia Vianna Von Bentzeen,Rosa Stella Silva,Morimoto Thomaz Takashi Ferreira,costa Verônica de Araújo Libânio,Silva Vitor Augusto Alves da,Batista Amanda Cypestre Alves,Viana Ana Flávia Gomes,Santos Ângela Rodrigues Vieira,Flores Anna Luiza Ribeiro,Dutra Arthur Guimarães Rodrigues,Maia Bruna Luiza,Almeida Clarisse Lourdes Nadú de,Barbosa Daniel Domingues,Medeiros Daniela Carla,Silva Daniele Saionara da,Rezende Diuly Ane Faria,Andrade Felipe Menezes,Batista Fernanda Rúbia,Reis Gabriela Ferreira,Paula Giovane Carvalho Constantino Ferreira de,Júnior Geovani de Araújo,Pires Henrique Amaral Fonseca,Silva Jéssica Aguilar,Rovetta Isabela Lovatti,Rangel Júlia Silva,Paula Júlia Lima Soares de,Costa Juliana Oliveira,Silva Lucas Júnio da,Dias Luiz Gustavo Fernandes,Oliveira Lívia Francino,Barros Lucas Rodrigues Pereira,Pessoa Lucas de Souza Gontijo,Silva Lucas Klier,Stabile Maria Luisa Lara Lanza,Pinto Mariana da Rocha Assis,Cunha Nicholas Vanzin,Silva Paloma Alister Vilela da,Soares Rafael Silva Rodrigues,Oliveira Thais Gomes de,Araújo Victor Oliveira de,Arcanjo Wesley Costa,Vanetti Alice Pinheiro,Santos Ana Carolina Araújo Lage,Freitas Ariade Gomes,Santos Felipe Viana,Pinheiro Fernanda Freitas,Rocha Fernanda Perez,Santos Filipe Viana,Marcolino Giulia de Jesus,Filho Humberto Drumond,Mendonça Isabela Gontijo,Faria Isadora Gomides,Milhomem José Victor Mendes,Mol Larissa Milagres,Costa Letícia de Fátima,Júnior Marcelo Bernardes Rocha,Miranda Maria Constâncio,Gonçalves Nathália Euclides,Ricco Suzana Cristina,Nascimento Thiago Araújo do,Pinheiro Amanda Luiza do Espírito Santo,Ferreira Ana Carolina Matos,Silva Ana Caroline Santos,Taveira Ana Luiza Silva,Lima Bruno Victor de Souza,Diana Débora Siqueira,Silveira Emanuela Pontes Pereira,Gonçalves Francisca Lina Campos,Costa Gabriel Corrêa,Souza Geraldo César Barroso de,Alves Guilherme Aurelio D'Oliveira,Neto Isadora Luiza Teixeira,Inácio Jordanna Porto,Silvério José Paulo Ribeiro,Marques Lara Silveira,Nascimento Larissa Martins do,Moreira Larissa Oliveira,Oliveira Lorena Luiza Soares de,Mussi Lucas Eduardo Lessa,Ruas Lucas Medeiros,Barbosa Luiza Nogueira Assis,Sousa Luiz Otávio de,Fernandes Marcelo Rodrigues da Costa,Souza Maria Eduarda Guimarães de,Calazans Maria Thereza Figueiredo Bélem,Bastos Mariana Rodrigues Marinho de,Alvarenga Pedro Henrique Arcanjo,Cujuí Quimberli Vassinave,Diniz Rafaela Valadares,Souza Rafael Cota Andrade Ferreira de,Silva Rita de Cássia,Corrêa Vinícius Alves,Oliveira Vinícius Carvalho de,Cunha Vitória Aparecida,Santos Viviane Costa,Almeida Ana Paula Figueiredo Guimarães de,Carvalho Ana Paula Guimarães Alves de,Jorge Antônio Henrique Batista,Ribeiro Artur Pimenta,Sena Elisângela Santos,Veloso Cleide Rocha,Murta Gonçalvino Eleutério,Cardoso Inara Maria Gomes,Alves João Warley,Veloso Jorge Fernando Rocha,Figueiredo Joyce Souto Barbosa Pimenta de,Lopes Karolina Campos Sampaio,Souza Larissa Vieira,Costa Loren Montanha,Souza Ludimila Pereira de,Lima Maria de Fátima César,Gonçalves Maria Izabel Silveira,Mendes Marizete Gislaine,Silva Mayra Darlliane Loiola,Fonseca Raissa Rocha e,Oliveira Samuel de Paiva,Ferro Thiago Rodrigues,Cruz Milagres Aline,Estevam Ana Carolina Aguiar,Oliveira Ana Martins de,Oliveira André Henrique de Sousa,Bitarães Carina,França Carla Stefany Oliveira,Freire Hayka K. Rodrigues,Gama Laís Aparecida dos Reis,Pereira Laylla Michelle,Silva Luciléia Alcântara Gomes e,Assis Patrícia Santana,Andrade Regiane Aparecida de,Silva Thaís de Paula Ferreira da,César Thiago de Alcântara,Rabelo Adriana Marcos Mendes,Rosa Aline do Carmo,Wherberth Ana Paula Vilas Boas,Souza André Gustavo Pinto de,Gomes André Luiz Souza,Oliveira Arthur Henrique Nunes Leite,Siqueira Damiana Rogai,Pinto Emanuel Peixoto,Oliveira Felipe Coelho Soares de,Damaceno Felipe Fraga,Rhis Guilherme,Almeida Iandra Silva,Borges Igor Barros de Araújo,Rocha Igor Brandão,Silva Jéssica Genoveva Boline Passarelli Capaz Pinto da,Júnior Jorge Carlos do Amaral,Marques José Pio,Vargas Laura Lima,Batista Lorena Cristina Ferreira,Fava Luiz Eduardo Coelho,Giles Luiza de Azevedo Freitas,Marques Marina Lacerda,Veríssimo Maura Alina Morais,Paula Neila Rodrigues Vargas de,Demuner Pâmela de Sousa Dias,Pouzas Ramail Santos,Marco Roberta Coelho de,Fernandes Rafaella Rosa de Oliveira,Mourão Ronan Figueiredo,Souza Sabrina Stefany da Silva,Ferraz Sara Silva,Amorim Ana Beatriz,Martins Carolina Francisca,Diniz Callegari Eduardo,Cordeiro Geovanna Carla,Lourenço Huisnei Ferreira,Santos João Victor Fagundes dos,Veloso João Pedro Donato,Santos Júlia Alves,Nogueira Júlia senra,Nascimento Jussara Carolina Assis Ribeiro,Martins Lavínia de Fátima Baldim,Menezes Lucca Batista Rocha de,Silva Maria Clara Damaso da,Santos Mariana das Graças de Aquino,Leão Rafael Augusto de Carvalho,Sales Solange Santos Moreira,Moreira Vitor Franco,Friedmann Amanda Diniz,Chaves Barbara Carvalho,Oliveira Janaína Leyner de Andrade,Diniz Júlia Silva,Braga Luiz Felipe de Oliveira,Duarte Luiza Gabriele Dutra,Duque Marcela Julia Rufino,Emiliano Mariana Cristina Flores,Silveira Rafaela Carolina,Moreira Virgínia Mara Santos,Bedetti Aline Dias,Campos Amanda Faria Simoni,Almeida Andressa de,Costa Anna Carolina Motta,Cunha Clara Tornelli de Almeida,Mascarenhas Cristiana Silva,silva Daniel Ananias da,Ribeiro Diana Antoniazzi de Sá,Brandão Diana Luiza Marinho,Morais Érico Henrique Araújo de,Soares Felipe César,Borba Flávia Marcella Sena Gonçalves,Gomes Karinna Guimarães,Estevam Marco Wellington Junio,Lopes Matheus Ramos,Santos Marina Eduarda,Silva Maryane de Oliveira,Silva Nágella Samara Eleutério da,Carneir Rafael Rocha,Silva Rayane Elen Fernandes,Wondollinger Ruan Carling Schott,Menezes Yuri Barbosa de,Rezende Bárbara Ellen Souza,Costa Catarina Giovanna Simões,Costa Gabriel Antônio Simões,Cardoso Gabriel Marcos theodoro,Sousa Graziela César de,Silva Graziele Aparecida,Campos Isabela Cristina de Oliveira,Souza Lara Silva,Rabello Laura Nacife,Oliveira Roberta Ellen Santos,Roberti Bárbara Nogueira,Garcia Bruno Reis,Gelape Bruno Rocha,Figueiredo Carina Daniela Lira Moreira,Cachoeira João Vitor Rocha,Santos Júlia Romano Ferreira,Silva Sarah de Resende,Rios Thalita Oliva,Quadros Túlio Fonseca e Silva,Barber Bethany,Capraru Camelia,Lemieux Camille,Li Daniel,Smookler David,Booth Joshua,Kuczynski Magdalena,Marquez Maria Kristina,Noureldin Seham,Jeganathan Shinthuka,Tharmaratnam Tharmegan,Aleyadeh Wesam,Powis Jeff,Taylor Maureen,Chan Adrienne,Salvant Elsa,Graham Christopher,Dagher Marc,Duarte William Parreira,Castro Duílio de,Silveira Flávio Pimenta,Ribeiro Alber Alípio,Medioli Vittorio,Rocha Augusto Viana da,Oliveira Hilton Soares de,Amaral Tânia Maria de Resende,Pereira Christiano Augusto Xavier,Tomé Nádia Cristina Dias Duarte,Pereira João Marcelo Diegues,Ribeiro Diogo Jonata,Souto Humberto Guimarães,Gonçalves Dulce Pimenta,Barcelos Avimar de Melo,Merlo André Luiz Coelho,Leite Edna Gomes,Sangali Caroline Martins,Santos Angelo Oswaldo de Araujo,Nascimento Glauciane Resende do,

Affiliation:

1. ViRx@Stanford, Stanford Biosecurity and Pandemic Preparedness Initiative, Stanford, California; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil; Department of Medicine, Pontifícia Universidade Católica de Minas Gerais, Minas Gerais, Brazil; and Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada (G.R.)

2. Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil, and Department of Medicine, Pontifícia Universidade Católica de Minas Gerais, Minas Gerais, Brazil (E.A.d.S.M.S., D.C.M.S., V.H.d.S.C., C.V.Q.d.S.)

3. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada (L.T., S.S., P.M., G.H.G.)

4. Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil (T.S.F., M.I.C.S., L.B.R., R.O.)

5. Public Health Care Division, City of Ibirité, Brazil (A.M.R.N.)

6. Department of Public Health at UNIFIPMoc and Family Medicine Fellowship Program, City of Montes Claros, Brazil (A.P.F.G.A.)

7. Public Health, Mental and Family Medicine Department, Ouro Preto Federal University, Minas Gerais, Brazil (L.C.M.S.)

8. Public Health Fellowship Program, Governador Valadares Public Health Authority, Minas Gerais, Brazil (A.D.d.F.N.)

9. Public Health, Mental and Family Medicine Department, Ouro Preto Federal University, Minas Gerais, Brazil, and Public Health Care Division, City of Ibirité, Brazil (C.B., A.C.M.)

10. Department of Public Health at UNIFIPMoc and Family Medicine Fellowship Program, City of Montes Claros, Brazil, and Public Health Care Division, City of Brumadinho, Brazil (E.D.C.)

11. Cytel, Vancouver, British Columbia, Canada (O.H., H.R.)

12. Platform Life Sciences, Vancouver, British Columbia, Canada (L.A.W., J.I.F., C.M.G., J.R.S.)

13. Certara, Princeton, New Jersey, and Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia (C.R.R.)

14. Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota (D.R.B.)

15. Department of Medicine, Division of Respiratory Medicine, McGill University Health Centre, Montréal, Québec, Canada (N.E.)

16. Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada (T.C.L.)

17. Division of General Internal Medicine, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada (E.G.M.)

18. School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom (M.B.)

19. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom (C.B.)

20. Global Health Institute, Georgetown University, Washington, DC (M.D.)

21. ViRx@Stanford, Stanford Biosecurity and Pandemic Preparedness Initiative, Stanford, California; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Cytel, Vancouver, British Columbia, Canada; and Platform Life Sciences, Vancouver, British Columbia, Canada (E.J.M.).

Funder

Latona Foundation

Rainwater Charitable Foundation

FastGrants

Publisher

American College of Physicians

Subject

General Medicine,Internal Medicine

Reference22 articles.

1. Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor

2. Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial

3. Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19