1. From Laboratory of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece; Center for Treatment Comparison and Integrative Analysis, Tufts Medical Center, Sackler School of Biomedical Sciences, and Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts, and Center for Evidence-based Medicine, Brown University School of Public Health, Providence, Rhode Island.