Temporal Improvements in COVID-19 Outcomes for Hospitalized Adults: A Post Hoc Observational Study of Remdesivir Group Participants in the Adaptive COVID-19 Treatment Trial

Author:

Potter Gail E.1ORCID,Bonnett Tyler2ORCID,Rubenstein Kevin2ORCID,Lindholm David A.3ORCID,Rapaka Rekha R.4,Doernberg Sarah B.5ORCID,Lye David C.6ORCID,Mularski Richard A.7ORCID,Hynes Noreen A.8ORCID,Kline Susan9,Paules Catharine I.10ORCID,Wolfe Cameron R.11ORCID,Frank Maria G.12ORCID,Rouphael Nadine G.13,Deye Gregory A.14ORCID,Sweeney Daniel A.15ORCID,Colombo Rhonda E.16,Davey Richard T.17ORCID,Mehta Aneesh K.18ORCID,Whitaker Jennifer A.19ORCID,Castro Jose G.20ORCID,Amin Alpesh N.21ORCID,Colombo Christopher J.22ORCID,Levine Corri B.23ORCID,Jain Mamta K.24ORCID,Maves Ryan C.25ORCID,Marconi Vincent C.26ORCID,Grossberg Robert27ORCID,Hozayen Sameh28ORCID,Burgess Timothy H.29ORCID,Atmar Robert L.30ORCID,Ganesan Anuradha31,Gomez Carlos A.32ORCID,Benson Constance A.33,Lopez de Castilla Diego34,Ahuja Neera35,George Sarah L.36,Nayak Seema U.14,Cohen Stuart H.37,Lalani Tahaniyat38,Short William R.39ORCID,Erdmann Nathaniel40,Tomashek Kay M.14ORCID,Tebas Pablo41ORCID

Affiliation:

1. Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland (G.E.P.)

2. Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland (T.B., K.R.)

3. Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, and Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, Texas (D.A.L.)

4. University of Maryland Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland (R.R.R.)

5. Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, California (S.B.D.)

6. National Centre for Infectious Diseases, Tan Tock Seng Hospital, Yong Loo Lin School of Medicine, and Lee Kong Chian School of Medicine, Singapore (D.C.L.)

7. Department of Pulmonary and Critical Care Medicine, Northwest Permanente PC, and Kaiser Permanente Northwest Center for Health Research, Portland, Oregon (R.A.M.)

8. Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland (N.A.H.)

9. Department of Medicine, Division of Infectious Diseases and International Medicine, University of Minnesota Medical School, Minneapolis, Minnesota (S.K.)

10. Division of Infectious Diseases, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania (C.I.P.)

11. Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina (C.R.W.)

12. Department of Medicine, Denver Health Hospital Authority, Denver, Colorado, and University of Colorado School of Medicine, Aurora, Colorado (M.G.F.)

13. Hope Clinic, Emory Vaccine Center, Infectious Diseases Division, Atlanta, Georgia (N.G.R.)

14. Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (G.A.D., S.U.N., K.M.T.)

15. Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, California (D.A.S.)

16. Madigan Army Medical Center, Tacoma, Washington, Infectious Diseases Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, and The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland (R.E.C.)

17. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (R.T.D.)

18. Division of Infectious Diseases, Emory University School of Medicine, and National Emerging Special Pathogens Training and Education Center, Atlanta, Georgia (A.K.M.)

19. Departments of Molecular Virology and Microbiology and Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas (J.A.W.)

20. Division of Infectious Diseases, University of Miami, Miami, Florida (J.G.C.)

21. Department of Medicine, University of California, Irvine, Irvine, California (A.N.A.)

22. Madigan Army Medical Center, Tacoma, Washington, and Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland (C.J.C.)

23. Department of Internal Medicine, Division of Infectious Disease, University of Texas Medical Branch, Galveston, Texas (C.B.L.)

24. Department of Internal Medicine, Division of Infectious Disease and Geographic Medicine, UT Southwestern Medical Center, and Parkland Health & Hospital System, Dallas, Texas (M.K.J.)

25. Wake Forest University School of Medicine, Winston-Salem, North Carolina, and Infectious Diseases Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland (R.C.M.)

26. Emory University School of Medicine, Rollins School of Public Health, and Atlanta Veterans Affairs Medical Center, Atlanta, Georgia (V.C.M.)

27. Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York (R.G.)

28. Department of Medicine, Division of Hospital Medicine, University of Minnesota, Minneapolis, Minnesota (S.H.)

29. Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland (T.H.B.)

30. Department of Medicine, Baylor College of Medicine, Houston, Texas (R.L.A.)

31. Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and Walter Reed National Military Medical Center, Bethesda, Maryland (A.G.)

32. Department of Internal Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska (C.A.G.)

33. Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, California (C.A.B.)

34. Division of Infectious Diseases, Evergreen Health Medical Center, Kirkland, Washington (D.L.)

35. Department of Internal Medicine, Stanford University Medical Center, Palo Alto, California (N.A.)

36. Saint Louis University and St. Louis VA Medical Center, Saint Louis, Missouri (S.L.G.)

37. Division of Infectious Diseases, University of California, Davis, Sacramento, California (S.H.C.)

38. Naval Medical Center Portsmouth, Portsmouth, Virginia, Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, and The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland (T.L.)

39. Department of Medicine, Division of Infectious Diseases, University of Pennsylvania, Philadelphia, Pennsylvania (W.R.S.)

40. Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama (N.E.)

41. Division of Infectious Diseases/Clinical Trials Unit, University of Pennsylvania, Philadelphia, Pennsylvania (P.T.).

Funder

National Institute of Allergy and Infectious Diseases

National Cancer Institute

Publisher

American College of Physicians

Subject

General Medicine,Internal Medicine

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