Affiliation:
1. Moscow State University
2. “GF Group” LLC
3. Lomonosov Moscow State University
4. Institute of Gene Biology Russian Academy of Sciences
5. FSGI “A.V. Vishnevsky National Medical Research Center of Surgery” Ministry of Health of Russia
Abstract
Growth factors (GFs) are endogenous signaling proteins, that regulate cell migration, proliferation and differentiation in tissue regeneration. GFs’ concentrations in chronic wounds are pathologically reduced. This leads to a disruption of the healing process and makes chronic wounds treatment more complicated. There are drugs currently used in clinical practice, that contain GFs in a free form. However, their efficiency for chronic wounds treatment is limited, as GFs are quickly degraded in a proteolytic environment of chronic wounds. In order to overcome this limitation biocompatible molecular systems for targeted delivery and controlled release are proposed, such as: micro- and nanoparticles, hydrogels, scaffolds. GFs roles in the healing process, chronic wounds pathophysiology and molecular systems for GFs targeted delivery and controlled release are reviewed.
Publisher
RPO Surgical Society - Wound and Wound Infections
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