Comparation between fluid bed granulation and high shear mixer as a techniques of choice for achieving optimum homogeneity for low dose solid pharmaceutical dosage form
Author:
Affiliation:
1. Replek Farm, Kozle 188, Skopje, North Macedonia
Publisher
Macedonian Pharmaceutical Association
Subject
General Engineering,Energy Engineering and Power Technology
Link
https://bulletin.mfd.org.mk/volumes/Volume%2069_3/69_3_084.pdf
Reference5 articles.
1. European Pharmacopeia 2022, 11th edition, Uniformity of dosage units’ p.421-423
2. Fayed, M.H., Abdel-Rahman, S.I., Alanazi, F.K., Ahmed, M.O., Tawfeek, H.M., 2020. An investigation into the impact of key process variables on the uniformity of powder blends containing a low-dose drug in a gentle-wing high shear mixer. J. Drug Deliv. Sci. Technol., 60, 10203. https://doi.org/10.1016/j.jddst.2020.102036
3. Kukkar, V., Anand, V., Kataria, M., Gera, M., Choudhury, P.K., 2008. Mixing and formulation of low dose drugs: underlying problems and solutions. Thai J. Pharm. Sci., 32(3-4), 43-58.
4. Mao, C., Thalladi, V.R., Kim, D.K., Ma, S.H., Edgren, D., Karaborni, S., 2013. Harnessing ordered mixing to enable direct-compression process for low-dose tablet manufacturing at production scale. Powder technology, 239, 290-299. DOI:10.1016/j.powtec.2013.02.016
5. Siew, A., 2018. Analyzing content uniformity. Pharm. Tech., 42(2), 16-22.
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