Affiliation:
1. Institute of Pathophysiology and Nuclear Medicine, Faculty of Medicine, Ss. Cyril and Methodious University, Mother Teresa 17, 1000 Skopje, Republic of North Macedonia
Abstract
Thyroid function tests are prone to analytical interference, which can cause misleading results when performed on automated immunoassay analyzers. We present a case of a 68-years old woman diagnosed with primary hypothyroidism and chronically treated with levothyroxine. Her status has been followed-up in several different institutions and before readmission to our institute, she was diagnosed as T3 toxicosis according to the lab results of suppressed TSH, normal FT4 and highly elevated FT3 values. Due to lack of toxic symptoms, our clinician suspected FT3 test interference, which was confirmed in our lab by performing the test on a different immunoassay platform. In conclusion, every discrepancy between clinical presentation and laboratory test results has to be inspected by close communication between clinicians and laboratory specialists. Our goal was to raise the awareness within the healthcare community about the interference in immunoassays affecting different kit manufacturers and analytical platforms in order to avoid erroneous diagnosis and mistreatment of patients.
Key words: immunoassay, interference, free triiodothyronine, mistreatment
Publisher
Macedonian Pharmaceutical Association
Reference26 articles.
1. Bartalena, L., Robbins, J., 1992. Variations in thyroid-hormone transport proteins and their clinical implications. Thyroid 2, 237–245. Available at: https://doi.org/10.1089/thy.1992.2.237.
2. Beato-Vibora, P.I., Alejo Gonzalez, S., 2017. Avoiding misdiagnosis of antibody interference with serum free hyroxin. Int. J. Endocrinol. Metab. 15(1), e37792. Available at: https://doi.org/10.5812/ijem.37792.
3. Beckett, G.J., Toft, A.D., 2003. First-line thyroid function tests – TSH alone is not enough. Clinical Endocrinology 58, 20–21. Available at: https://doi.org/10.1046/j.1365-2265.2003.01690.x.
4. Biondi, B., Bartalena, L., Cooper, D.S., Hegedus, L., Laurberg, P., Kahaly, G.J., 2015. The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism. Eur. Thyroid J. 4(3), 149-163. Available at: https://doi.org/10.1159/000438750.
5. British Thyroid Association, 2006. UK Guidelines for the use of thyroid function tests. Available at: http://www.british-thyroidassociation.org/info-forpatients/DocsTFTguideline_final_version_ July_2006.
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