Liver transplantation for primary biliary cholangitis (review)

Author:

Iljinsky I. M.1,Tsirulnikova O. M.2

Affiliation:

1. Shumakov National Medical Research Center of Transplantology and Artificial Organs

2. Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University

Abstract

Primary biliary cholangitis (PBC) is an autoimmune liver disease resulting from the destruction and inflammation of intrahepatic bile ducts. This end-stage disease was once the most common cause of liver transplantation. The use of ursodeoxycholic and obeticholic acids as a first-line and second-line treatment, respectively, slows down the disease. However, treatment is not effective in about 40% of PBC patients, and the disease may progress to cirrhosis and end-stage liver disease. These patients undergo liver transplantation to save their lives. After surgery, recurrent PBC can develop in a milder form and rarely requires liver retransplantation.

Publisher

V.I. Shimakov Federal Research Center of Transplantology and Artificial Organs

Subject

Transplantation,Immunology and Allergy

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