Antibody-mediated rejection in heart transplantation-Reference-Cited by-同舟云学术

Antibody-mediated rejection in heart transplantation

Published:2021-11-12 Issue:4 Volume:23 Page:47-61
ISSN:2412-6160
Container-title:Russian Journal of Transplantology and Artificial Organs
language:
Short-container-title:RJTAO

Author:

Kvan V. S.¹,Koloskova N. N.¹,Kachanova Yu. A.¹,Sayfullina N. N.¹,Goncharova A. Yu.¹,Krugly L. B.¹,Shevchenko A. O.²

Affiliation:

1. Shumakov National Medical Research Center of Transplantology and Artificial Organs

2. Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University; Pirogov Russian National Research Medical University

Abstract

The role of antibody-mediated rejection in predicting survival among heart recipients has been studied in clinical transplantology for over 20 years. This condition is a significant risk factor for heart failure and graft vasculopathy. Antibody-mediated rejection results from activation of the humoral immune system and production of donorspecific antibodies that cause myocardial injury through the complement system. The presence of donor-specific antibodies is associated with lower allograft survival. Treatment of antibody-mediated rejection should take into account the rejection category and the presence or absence of graft dysfunction. The main principle of treatment is to suppress humoral immunity at different levels. World clinical practice has made significant inroads into the study of this issue. However, further research is required to identify and develop optimal treatment regimens for patients with humoral rejection in cardiac transplantation.

Publisher

V.I. Shimakov Federal Research Center of Transplantology and Artificial Organs

Subject

Transplantation,Immunology and Allergy

Reference53 articles.

1. Berry GJ, Burke MM, Andersen C et al. The 2013 International Society for Heart and Lung Transplantation Working Formulation for Standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation. J Heart Lung Transplant. 2013; 32: 1147–1162.

2. Hammond EH, Yowell RL, Nunoda S et al. Vascular (humoral) rejection in heart transplantation: pathologic observations and clinical implications. J Heart transplant. 1989; 8: 430–443.

3. Takemoto SK, Zeevi A, Feng S et al. National conference to assess antibodymediated rejection in solid organ transplantation. Am J Transplant. 2004; 4: 1033–1041.

4. Kfoury AG, Miller DV. The impact of asymptomatic antibody- mediated rejection on outcome after heart transplantation. Current Opinion in Organ Transplantation. 2019; 24 (3): 259–264. doi: 10.1097/mot.0000000000000640.

5. Kobashigawa J, Crespo-Leiro MG, Eisminger SM et al. Report from a consensus conference on antibody-mediated rejection in heart transplantation. J Heart Lung Transplant. 2011; 30: 252–269. doi: 10.1016/j.healun.2010.11.003.