RESULTS OF EXPERIMENTAL STUDIES OF THE CHILDREN’S AXIAL PUMP «DON-3»-Reference-Cited by-同舟云学术

RESULTS OF EXPERIMENTAL STUDIES OF THE CHILDREN’S AXIAL PUMP «DON-3»

Published:2018-06-27 Issue:2 Volume:20 Page:61-68
ISSN:2412-6160
Container-title:Russian Journal of Transplantology and Artificial Organs
language:
Short-container-title:RJTAO

Author:

Itkin G. P.¹,Dmitrieva O. Yu.²,Buchnev A. S.²,Drobyshev A. A.²,Kuleshov A. P.²,Volkova A. V.²,Halilulin T. A.³

Affiliation:

1. V.I. Shumakov National Medical Research Center of Transplantology and Artiﬁ cial Organs of the Ministry of Healthcare of the Russian Federation; Moscow Institute of Physics and Technology, Department of physics of living systems.

2. V.I. Shumakov National Medical Research Center of Transplantology and Artiﬁ cial Organs of the Ministry of Healthcare of the Russian Federation.

3. V.I. Shumakov National Medical Research Center of Transplantology and Artiﬁ cial Organs of the Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University).

Abstract

Aim.To evaluate the functioning of an implantable pediatric axial pump «DON-3» for bypassing the left ventricle of the heart in experiments on sheep.Materials and methods. Five sheeps at the age of 12–18 months performed paracorporeal installation of the children’s axial pump «DON-3» according to the scheme «left ventricle – aorta».Results.A technique was developed and 5 chronic experiments were conducted on sheep to assess the model of the children’s axial pump «DON-3». The duration of the experiments in this series averaged 9 ± 5 days. The main indicators of hemodynamics, acid-base balance were within the norm. Conducted morphological and histological studies of the kidneys, liver and lungs did not reveal the presence of zones of ischemia and thromboembolism.Conclusion.The results of this series of experiments showed satisfactory results, suggesting further research on the development of prototypes of a pediatric pump for clinical practice.

Publisher

V.I. Shimakov Federal Research Center of Transplantology and Artificial Organs

Subject

Transplantation,Immunology and Allergy

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