Autotransplantation of T-lymphocytes as a tool for antigen-specific immunotherapy of oncological diseases

Abstract

Autotransplantation of immune cells to induce immunological rejection of tumors can be a useful approach in tumor treatment. Despite the low efficiency of this  approach demonstrated in the past, the active development of cell technologies and  genetic engineering has led to the significant improvement in clinical outcomes. A  great success was achieved in adoptive immunotherapy with the T-lymphocytes  specific to tumor antigens. This review describes the clinical experience in  application of various antigen-specific adoptive immunotherapy methods including  tumor-infiltrating T-lymphocytes, T-lymphocytes with redirected transgenic T-cell  and chimeric antigenrecognizing receptors. The possibilities and limitations of these  biomedical technologies are also analyzed in the article.