Diagnostic possibilities of using micro-RNA for kidney transplantation

Abstract

Allogeneic kidney transplantation is the optimal approach for the treatment of patients with terminal stage of chronic kidney disease. Moreover, post-transplant  monitoring and optimization of immunosuppressive therapy with early non-invasive  molecular-biological markers can significantly improve the long-term outcome of  transplantation. As markers of damage to the kidney transplant, it is proposed to  use micro-RNAs that play a fundamental role in the regulation of the activity of  various genes. The level of expression of micro-RNA in different tissues can  correlate with certain pathological conditions. In this review, the literature data on  the study of the perspectives for the use of micro-RNA as biomarkers of the post-transplantation period in kidney transplant recipients are considered.