HISTOLOGICAL CHARACTERISTICS OF THE QUILTY EFFECT-Reference-Cited by-同舟云学术

HISTOLOGICAL CHARACTERISTICS OF THE QUILTY EFFECT

Published:2015-10-09 Issue:3 Volume:17 Page:14-23
ISSN:2412-6160
Container-title:Russian Journal of Transplantology and Artificial Organs
language:
Short-container-title:RJTAO

Author:

Iljinsky I. M.¹,Alexeeva L. S.²,Kurenkova L. G.²,Shevchenko A. O.²,Saitgareev R. Sh.²,Poptsov V. N.¹

Affiliation:

1. V.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation I.M. Sechenov First Moscow State Medical University, Department of transplantology and artifi cial organs, Moscow, Russian Federation

2. V.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation

Abstract

Aim. Identifi cation of possible histological differences of the Quilty effect in acute rejection and its absence as well as studying the proliferation of blood and lymph vessels in the area of Quilty damage.Materials and methods. 883 endomyocardial biopsy materials from 352 patients were studied. Histological sections were stained with hematoxylin and eosin, Masson method; the endothelium of lymphatic vessels was stained with immunoperoxidase method using a marker D2-40.Results. The Quilty effect was observed both in acute rejection and inits absence. In the majority of cases the Quilty effect was of type «A» and it was combined with acute rejection. The Quilty effect of type «B» has been mostly in the G2R. Acute rejection is characterized by diffuse form of endocardium lymphoid infi ltration. Follicular form resembles lymphoid organ tissue. Different types and forms of the Quilty effect may be combined in the same biopsy. Proliferation of blood vessels presents in the area of the Quilty effect. Lymphatic vessels are missing in endocardium and in the area of the Quilty effect. They could be found only in the myocardium of endomiocardial biopsy.Conclusion. Diffuse lymphoid infi ltration of the endocardium is a characteristic feature of acute rejection of the transplanted heart. Follicular form of the Quilty effect is similar to lymphoid tissue whose role requires further study using immunohistochemical methods.

Publisher

V.I. Shimakov Federal Research Center of Transplantology and Artificial Organs

Subject

Transplantation,Immunology and Allergy

Reference15 articles.

1. Kottke-Marchant K, Ratliff NB. Endomyocardial lymphocytic infi ltrates in cardiac transplant recipients. Incidence and characterization. Arch Pathol Lab Med. 1989 Jun; 113 (6): 690–698.

2. Gopal S, Narasimhan U, Day JD, Gao R, Kasper EK, Chen CL et al. The Quilty lesion enigma: focal apoptosis/ necrosis and lymphocyte subsets in human cardiac allografts. Pathol Int. 1998 Mar; 48 (3): 191–198.

3. Joshi A, Masek MA, Brown BW Jr, Weiss LM, Billingham ME. «Quilty» revisited: a 10-year perspective. Hum Pathol. 1995 May; 26 (5): 547–557.

4. Stewart S, Winters GL, Fishbein MC, Tazelaar HD, Kobashigawa J, Abrams J et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005 Nov; 24 (11): 1710–1720.

5. Hunt S, Burch M, Geetha B, Canter C, Chinnock R, Crespo-Leiro M. The international society of heart and lung transplantation guidelines for the care of heart transplant recipients, task force3: long-term care of heart transplant recipients. J Heart Lung Transplant. 2010: 914–956.