Vaccination against viral hepatitis b in pediatric liver transplant recipients

Author:

Zhilkin V. I.1,Tsiroulnikova O. M.2

Affiliation:

1. V.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation.

2. I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation, Department of transplantology and artifi cial organs (Sechenovskiy University); V.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation.

Abstract

Durable protection from hepatitis B virus (HBV) and other vaccine-preventable diseases assumes great importance due to improved long-term patient and graft survival rates in pediatric liver transplantation (PLT). Vaccine immunogenicity data in transplanted children is limited. The review presents aspects of current approach for childhood HBV immunization schedule prior to transplant, duration of time since transplant for receive booster dose, target median HBsAb levels before and after PLT. The latest data about types of vaccine against HBV and vaccine effectiveness in PLT centers in the world are also presented.

Publisher

V.I. Shimakov Federal Research Center of Transplantology and Artificial Organs

Subject

Transplantation,Immunology and Allergy

Reference44 articles.

1. Готье СВ, Константинов БА, Цирульникова ОМ. Трансплантация печени. М.: МИА, 2008. Gautier SV, Konstantinov BA, Tsirulnikova OM. Transplantatsiya pecheni. M.: MIA, 2008.

2. Danzinger-Isakov L, Kumar D. Guidelines for Vaccination of Solid Organ Transplant Candidates and Recipients. Am. J. Transplant. Dec. 2009; 9: S258–S262.

3. Weinbaum CM, Mast EE, and Ward JW. Recommendations for identifi cation and public health management of persons with chronic hepatitis B virus infection. Hepatology. May 2009; 49; S5: S35–S44.

4. HBV FAQs for Health Professionals | Division of Viral Hepatitis | CDC. [Online]. Available: https://www.cdc.gov/hepatitis/hbv/hbvfaq.htm. [Accessed: 19-Sep-2017].

5. WHO | Hepatitis B, WHO. [Online]. Available: http:// www.who.int/mediacentre/factsheets/fs204/en/. [Accessed: 19-Sep-2017].

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