MicroRNAs in heart transplant recipients-Reference-Cited by-同舟云学术

MicroRNAs in heart transplant recipients

Published:2017-06-23 Issue:2 Volume:19 Page:126-132
ISSN:2412-6160
Container-title:Russian Journal of Transplantology and Artificial Organs
language:
Short-container-title:RJTAO

Author:

Velikiy D. A.¹,Gichkun O. E.²,Shevchenko O. P.²

Affiliation:

1. V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation

2. V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation

Abstract

This review summarizes the current literature dedicated to the analysis of prognostic role of microRNAs in rejection of the transplanted heart. MicroRNAs are a class of small non-coding RNAs that regulate gene expression and affect various cellular functions. Variations of their profiles are noted at various pathological processes and rejection of solid organs. Presumably, measuring the level of microRNAs in heart transplant may have diagnostic and prognostic value in the assessment of risk of rejection and possibility of minimizing immunosuppressive therapy. Currently, accumulated clinical data on the role of the given biomarkers in heart transplantation are not enough, and further research on the relation of microRNAs levels and different clinical and laboratory parameters in heart recipients is necessary.

Publisher

V.I. Shimakov Federal Research Center of Transplantology and Artificial Organs

Subject

Transplantation,Immunology and Allergy

Reference72 articles.

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