Affiliation:
1. All-Russian Scientifc Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientifc Institution “Federal Scientifc Centre VIEV”
2. A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences
3. Kh. I. Ibragimov Complex Research Institute of the Russian Academy of Sciences
Abstract
The purpose of the research is to study effects of the 2.0% supramolecular complex of ivermectin in overdoses on the clinical condition of horses.Materials and methods. The experiment was conducted on 20 horses of different breeds in the Seradin Equestrian Center, the North Caucasus Federal District, the Chechen Republic, in October 2020. The horses were divided according to the principle of analogues into 3 test groups and one control group of 5 animals each. The 2.0% supramolecular complex of ivermectin was administered to the horses from group 1 at a therapeutic dose of 0.2 mg/kg; group 2 received a tripled dose of 0.6 mg/kg, and the group 3, a 5-fold increased dose of 1,0 mg/kg for the active substance. The drug was administered once individually in a mixture with compound feed. The body temperature was measured with a non-contact thermometer, and the pulse rate and the respiratory rate were measured per 1 min. Urine of the horses was examined on days 1, 7 and 14 after the drug. The urine color, transparency and consistency were determined. Multifunctional test paper was used to study pH, protein, glucose, ketone bodies, nitrites, bilirubin, and urobilinogen. Blood was taken in the morning from the horses’ jugular vein on days 1, 7 and 14 after the drug. Hematological and biochemical parameters were studied on analyzers.Results and discussion. Clinical fndings of the horses (body temperature, pulse and respiration) did not differ from those of the control animals after the 2.0% supramolecular complex of ivermectin was administered in a therapeutic, tripled and 5-fold increased doses on days 1, 7 and 14. A slight increase in ketone bodies was observed in the urine on day 1, which may indicate the drug effect on the central nervous system at a 5-fold increased dose; all parameters were within the normal range on days 7 and 14. The 2.0% supramolecular complex of ivermectin in overdoses (0.6; 1.0 mg/kg for the active substance) did not adversely affect the horses’ hematological or biochemical blood parameters.
Publisher
Institute of Fundamental and Applied Parasitology of Animals and Plants
Reference11 articles.
1. Arkhipov I. A. Anthelmintics: pharmacology and application. Moscow, Russian Agricultural Academy, 2009; 405. (In Russ.)
2. Arkhipov I. A., Khalikov S. S., Dushkin A. V., Polyakov N. E., Musaev M. B. Application of nano- and mechanochemical technology and targeted delivery for the development of innovative anthelmintics. «Teoriya i praktika bor'by s parazitarnymi boleznyami»: materialy dokladov Mezhdunarodnoy nauchnoy konferentsii Vserossiyskogo obshchestva gel'mintologov RAN = «Teory and practice of parasitic disease control”: materials of reports of the International Scientifc Conference of the All-Russian Society of Helminthologists of RAS. Moscow, 2016; 17: 30-36. (In Russ.)
3. Dvoynos G. M. Strongylids (Nematoda: Stronygidae) of domestic and wild horses: avtoref. dis. … Dr. Sc. Biol. Kyev, 1993; 39.
4. Zaschepkina V. V., Musaev M. B. Preclinical studies of ivermectin solid dispersion. «Teoriya i praktika bor'by s parazitarnymi boleznyami»: materialy dokladov Mezhdunarodnoy nauchnoy konferentsii Vserossiyskogo obshchestva gel'mintologov RAN = «Teory and practice of parasitic disease control”: materials of reports of the International Scientifc Conference of the All-Russian Society of Helminthologists of RAS. Мoscow, 2019; 20: 231-237. (In Russ.) https://doi.org/10.31016/978-5-9902340-8-6.2019.20.231-237
5. Zashchepkina V. V. Acute oral toxicity of the supramolecular complex of ivermectin. Rossiyskiy parazitologicheskiy zhurnal = Russian Journal of Parasitology. 2020; 14 (1): 59–63. (In Russ.) https://doi.org/10.31016/1998-8435-2020-14-1-59-63
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献