Modifcation of anthelmintic drugs by nanotechnology (review)

Author:

Varlamova A. I.1ORCID,Arkhipov I. A.1ORCID,Khalikov S. S.2ORCID,Arisov M. V.1ORCID

Affiliation:

1. All-Russian Scientifc Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientifc Institution “Federal Scientifc Centre VIEV”

2. A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences

Abstract

The purpose of the research is to analyze and summarize the literature data and the results of our own studies on the use of drug delivery systems and methods for increasing the solubility and efcacy of anthelmintic drugs.Helminthoses are one of the most important problems in veterinary medicine and animal husbandry, not only due to the pathological effects, but also due to the spread of anthelmintic resistance. Since the development of new anthelmintic substances takes many years and investment, some strategies are currently focused on modifying existing drugs to increase their efcacy, reduce side effects and overcome anthelmintic resistance. Literature data analysis on various methods and means of increasing the solubility and efcacy of anthelmintic drugs was carried out and the prospects for their use, including using modern nanotechnological methods of drug delivery were given.

Publisher

Institute of Fundamental and Applied Parasitology of Animals and Plants

Reference80 articles.

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5. Arkhipov I. A., Khalikov S. S., Dushkin A. V., Polyakov N. E., Musaev M. B., Varlamova A. I., et al. Application of nano- and mechanochemical technology and targeted delivery for development of innovative anthelmintic drugs. «Teoriya i praktika bor'by s parazitarnymi boleznyami»: materialy dokladov Mezhdunarodnoy nauchnoy konferentsii Vserossiyskogo obshchestva gel'mintologov RAN = «Teory and practice of parasitic disease control”: materials of reports of the International Scientifc Conference of the All-Russian Society of Helminthologists of RAS. 2016; 17: 30-36. (In Russ.)

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